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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Lysophosphatidic acid receptor 3
Species	Homo sapiens (Human)
Gene	LPAR3
Synonym	Lysophosphatidic acid receptor Edg-7 LPA3 receptor LPA-3 LPA receptor 3 endothelial differentiation gene 7, lysophosphatidic acid G-protein-coupled receptor 7 Edg7 [ Show all ]
Disease	Fibrosis
Length	353
Amino acid sequence	MNECHYDKHMDFFYNRSNTDTVDDWTGTKLVIVLCVGTFFCLFIFFSNSLVIAAVIKNRKFHFPFYYLLANLAAADFFAGIAYVFLMFNTGPVSKTLTVNRWFLRQGLLDSSLTASLTNLLVIAVERHMSIMRMRVHSNLTKKRVTLLILLVWAIAIFMGAVPTLGWNCLCNISACSSLAPIYSRSYLVFWTVSNLMAFLIMVVVYLRIYVYVKRKTNVLSPHTSGSISRRRTPMKLMKTVMTVLGAFVVCWTPGLVVLLLDGLNCRQCGVQHVKRWFLLLALLNSVVNPIIYSYKDEDMYGTMKKMICCFSQENPERRPSRIPSTVLSRSDTGSQYIEDSISQGAVCNKSTS
UniProt	Q9UBY5
Protein Data Bank	N/A
GPCR-HGmod model	Q9UBY5
3D structure model	This predicted structure model is from GPCR-EXP Q9UBY5.
BioLiP	N/A
Therapeutic Target Database	T95923
ChEMBL	CHEMBL3250
IUPHAR	274
DrugBank	N/A

Ligand

Name	CHEMBL2017139
Molecular formula	C22H45O6PS
IUPAC name	(3-dihydroxyphosphinothioyloxy-2-methoxypropyl) octadecanoate
Molecular weight	468.63
Hydrogen bond acceptor	7
Hydrogen bond donor	2
XlogP	8.4
Synonyms	BDBM50381022
Inchi Key	AYKYANCQUONAPE-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H45O6PS/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-22(23)27-19-21(26-2)20-28-29(24,25)30/h21H,3-20H2,1-2H3,(H2,24,25,30)
PubChem CID	46223906
ChEMBL	CHEMBL2017139
IUPHAR	N/A
BindingDB	50381022
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
EC50	0.2754 nM	PMID23395664	ChEMBL
EC50	0.28 nM	PMID23395664	BindingDB
EC50	0.28 nM	PMID23395664	ChEMBL
Intrinsic activity	410.0 -	PMID23395664	ChEMBL

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