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GPCR

Name5-hydroxytryptamine receptor 2B
SpeciesRattus norvegicus (Rat)
GeneHtr2b
Synonymstomach fundus serotonin receptor
serotonin receptor 2B
5-HT-2B
5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
5-HT2F
[ Show all ]
DiseaseN/A for non-human GPCRs
Length479
Amino acid sequenceMASSYKMSEQSTISEHILQKTCDHLILTDRSGLKAESAAEEMKQTAENQGNTVHWAALLIFAVIIPTIGGNILVILAVSLEKRLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEATWPLPLALCPAWLFLDVLFSTASIMHLCAISLDRYIAIKKPIQANQCNSRTTAFVKITVVWLISIGIAIPVPIKGIEADVVNAHNITCELTKDRFGSFMLFGSLAAFFAPLTIMIVTYFLTIHALRKKAYLVRNRPPQRLTRWTVSTVLQREDSSFSSPEKMVMLDGSHKDKILPNSTDETLMRRMSSAGKKPAQTISNEQRASKVLGIVFLFFLLMWCPFFITNVTLALCDSCNQTTLKTLLQIFVWVGYVSSGVNPLIYTLFNKTFREAFGRYITCNYQATKSVKVLRKCSSTLYFGNSMVENSKFFTKHGIRNGINPAMYQSPVRLRSSTIQSSSIILLNTFLTENDGDKVEDQVSYI
UniProtP30994
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL323
IUPHAR7
DrugBankN/A

Ligand

NameLY-193525
Molecular formulaC22H29N3O
IUPAC name(6aR,9R,10aR)-N-cyclohexyl-7-methyl-6,6a,8,9,10,10a-hexahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide
Molecular weight351.494
Hydrogen bond acceptor2
Hydrogen bond donor2
XlogP3.5
SynonymsLY 193525
BDBM84933
6-Methyl-N-cyclohexylergoline-8A?A(2)-carboxamide
CHEMBL422708
Inchi KeyKOFNTRSDRGFTGZ-XFQXTVEOSA-N
Inchi IDInChI=1S/C22H29N3O/c1-25-13-15(22(26)24-16-6-3-2-4-7-16)10-18-17-8-5-9-19-21(17)14(12-23-19)11-20(18)25/h5,8-9,12,15-16,18,20,23H,2-4,6-7,10-11,13H2,1H3,(H,24,26)/t15-,18-,20-/m1/s1
PubChem CID44373084
ChEMBLN/A
IUPHARN/A
BindingDB84933
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki9.55 nMPMID8632342BindingDB

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