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GPCR

NameGalanin receptor type 1
SpeciesHomo sapiens (Human)
GeneGALR1
SynonymGAL1-R
GALNR
GALNR1
GALR-1
GAL1 receptor
DiseaseEpileptic seizures
Length349
Amino acid sequenceMELAVGNLSEGNASWPEPPAPEPGPLFGIGVENFVTLVVFGLIFALGVLGNSLVITVLARSKPGKPRSTTNLFILNLSIADLAYLLFCIPFQATVYALPTWVLGAFICKFIHYFFTVSMLVSIFTLAAMSVDRYVAIVHSRRSSSLRVSRNALLGVGCIWALSIAMASPVAYHQGLFHPRASNQTFCWEQWPDPRHKKAYVVCTFVFGYLLPLLLICFCYAKVLNHLHKKLKNMSKKSEASKKKTAQTVLVVVVVFGISWLPHHIIHLWAEFGVFPLTPASFLFRITAHCLAYSNSSVNPIIYAFLSENFRKAYKQVFKCHIRKDSHLSDTKESKSRIDTPPSTNCTHV
UniProtP47211
Protein Data BankN/A
GPCR-HGmod modelP47211
3D structure modelThis predicted structure model is from GPCR-EXP P47211.
BioLiPN/A
Therapeutic Target DatabaseT78581
ChEMBLCHEMBL4894
IUPHAR243
DrugBankN/A

Ligand

NameCHEMBL1921988
Molecular formulaC22H23F2N5O
IUPAC name4-N-[4-(difluoromethoxy)phenyl]-6-N-phenyl-2-piperidin-1-ylpyrimidine-4,6-diamine
Molecular weight411.457
Hydrogen bond acceptor8
Hydrogen bond donor2
XlogP6.2
SynonymsBDBM50358664
SCHEMBL10144353
Inchi KeyKKYLHZLMVCIIRM-UHFFFAOYSA-N
Inchi IDInChI=1S/C22H23F2N5O/c23-21(24)30-18-11-9-17(10-12-18)26-20-15-19(25-16-7-3-1-4-8-16)27-22(28-20)29-13-5-2-6-14-29/h1,3-4,7-12,15,21H,2,5-6,13-14H2,(H2,25,26,27,28)
PubChem CID57394235
ChEMBLCHEMBL1921988
IUPHARN/A
BindingDB50358664
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Inhibition60.0 %PMID22018787ChEMBL

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