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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 6
Species	Homo sapiens (Human)
Gene	HTR6
Synonym	5-HT6 receptor 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 5-HT-6 serotonin receptor 6 ST-B17 5-HT6 [ Show all ]
Disease	Schizophrenia Obesity Neurological disease Neurodegenerative disease Emesis Cognitive disorders Unspecified Anxiety disorder Alzheimer disease; Dementia Alzheimer disease; Anxiety disorder Alzheimer disease [ Show all ]
Length	440
Amino acid sequence	MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN
UniProt	P50406
Protein Data Bank	N/A
GPCR-HGmod model	P50406
3D structure model	This predicted structure model is from GPCR-EXP P50406.
BioLiP	N/A
Therapeutic Target Database	T16691
ChEMBL	CHEMBL3371
IUPHAR	11
DrugBank	BE0000945

Ligand

Name	Glemanserin
Molecular formula	C20H25NO
IUPAC name	phenyl-[1-(2-phenylethyl)piperidin-4-yl]methanol
Molecular weight	295.426
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	3.8
Synonyms	(+-)-1-Phenethyl-alpha-phenyl-4-piperidinemethanol 4-Piperidinemethanol, alpha-phenyl-1-(2-phenylethyl)- alpha-phenyl-[1-(2-phenylethyl )]-4-piperidinemethanol CHEMBL18972 Glemanserin [USAN:INN] Mdl 11939 RT-013670 (1-phenethylpiperidin-4-yl)-phenylmethanol AXNGJCOYCMDPQG-UHFFFAOYSA-N D05MFO J-002002 MolPort-003-983-619 SR-01000597432-1 132553-86-7 AKOS024458672 CHEBI:91790 MDL 11,939 phenyl-[1-(2-phenylethyl)-4-piperidyl]methanol (1-Phenethyl-piperidin-4-yl)-phenyl-methanol 4-Piperidinemethanol, alpha-phenyl-1-(2-phenylethyl)-, (+-)- alpha-phenyl-[1-(2-phenylethyl)]-4-piperidinemethanol CTK8D3348 GTPL186 Mdl-11,939 SCHEMBL120012 AC1L2GSP BDBM50004327 DTXSID4042624 L002081 PDSP1_001574 ( inverted exclamation markA)-1-phenethyl-a-phenyl-4-piperidinemethanol alpha-Phenyl-1-(2-phenylethyl)-4-piperidinemethanol Glemanserin (USAN/INN) MDL 11,939phenyl[1-(2-phenylethyl)piperidin-4-yl]methanol phenyl-[1-(2-phenylethyl)piperidin-4-yl]methanol (1-phenethylpiperidin-4-yl)(phenyl)methanol 4-Piperidinemethanol,a-phenyl-1-(2-phenylethyl)- AN-24938 D04320 HMS3266L14 MDL-11939 SR-01000597432 107703-78-6 AC1Q771C BRD-A62057054-001-01-5 FT-0703731 LS-172057 PDSP2_001558 [ Show all ]
Inchi Key	AXNGJCOYCMDPQG-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H25NO/c22-20(18-9-5-2-6-10-18)19-12-15-21(16-13-19)14-11-17-7-3-1-4-8-17/h1-10,19-20,22H,11-16H2
PubChem CID	71781
ChEMBL	CHEMBL18972
IUPHAR	186
BindingDB	50004327
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	2752.0 nM	PMID15999145	PDSP,BindingDB

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