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GPCR

Name	Alpha-2C adrenergic receptor
Species	Homo sapiens (Human)
Gene	ADRA2C
Synonym	alpha2-C4 Adra-2c ADRA2L2 ADRA2RL2 Adrenergic alpha2C- receptor class I adrenergic receptor alpha-2 adrenergic receptor subtype C4 alpha2C-adrenoceptor alpha-2C adrenergic receptor Alpha-2C adrenoceptor alpha-2C adrenoreceptor Alpha-2CAR [ Show all ]
Disease	Diabetic nephropathy; Fibromyalgia Hypertension Heart failure Glaucoma Alzheimer disease Asthma Erythema Contusion Depression Hypotension Male sexual disorders Neurological disease Obesity Ocular disease Allergic rhinitis Alcohol use disorders Ocular hypertension Poison intoxication Peptic ulcer Pain [ Show all ]
Length	462
Amino acid sequence	MASPALAAALAVAAAAGPNASGAGERGSGGVANASGASWGPPRGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSLYRQPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLSEKRAPVGPDGASPTTENGLGAAAGAGENGHCAPPPADVEPDESSAAAERRRRRGALRRGGRRRAGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRLSRASSRSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ
UniProt	P18825
Protein Data Bank	N/A
GPCR-HGmod model	P18825
3D structure model	This predicted structure model is from GPCR-EXP P18825.
BioLiP	N/A
Therapeutic Target Database	T01777
ChEMBL	CHEMBL1916
IUPHAR	27
DrugBank	BE0004864, BE0000342, BE0004888

Ligand

Name	Pipamperone
Molecular formula	C21H30FN3O2
IUPAC name	1-[4-(4-fluorophenyl)-4-oxobutyl]-4-piperidin-1-ylpiperidine-4-carboxamide
Molecular weight	375.488
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	2.0
Synonyms	[1,4'-Bipiperidine]-4'-carboxamide,1'-[4-(4-fluorophenyl)-4-oxobutyl]- 5402501F0W BRD-K26801045-001-01-1 CHEMBL440294 Dipiperone L000727 p-Fluoro-.gamma.-(4-piperidino-4-carbamoylpiperidino)butyrophenone Pipamperona [INN-Spanish] (1,4'-Bipiperidine)-4'-carboxamide, 1'-(4-(4-fluorophenyl)-4-oxobutyl)- Pipamperonum [INN-Latin] 1'-[4-(4-Fluorophenyl)-4-oxobutyl]-[1,4'-bipiperidine]-4'-carboxamide R4050 150093-EP2280012A2 2448-68-2 (di-hydrochloride) AB01563106_01 Carpiperone D02622 Fluoropipamide NCGC00165864-01 PDSP1_001560 PIPAMPERONE DIHYDROCHLORIDE APPROX. 99 1'-(3-(4-fluorobenzoyl)propyl)-(1,4'-bipiperidine) -4'-carboxamide Piperonyl 1,4'-Bipiperidine]-4'-carboxamide, 1'-[4-(4-fluorophenyl)-4-oxobutyl]- SR-05000001930 ZINC21297287 4'-Fluoro-4-(4-N-piperidino-4-carbamidopiperidino)butyrophenone AXKPFOAXAHJUAG-UHFFFAOYSA-N CCRIS 9071 Dipiperal Isonipacotamide, 1-(3-(p-fluorobenzoyl)propyl)-4-piperidino- NSC759178 Pipamperon Pipamperone [USAN:INN:BAN] 1'-(4-(4-fluorophenyl)-4-oxobutyl)-1,4'-bipiperidine-4'-carboxamide R 3345 1-[4-(4-fluorophenyl)-4-oxo-butyl]-4-(1-piperidyl)piperidine-4-carboxamide BRN 0496532 CTK7F7159 DTXSID8048369 LS-44586 p-Fluoro-gamma-(4-piperidino-4-carbamoylpiperidino)butyrophenone Pipaneperone 1'-[4-(4-Fluorophenyl)-4-oxobutyl]-[1,4'-bipiperidine]-4'-carboxamide Hydrochloride SBI-0206899.P001 150093-EP2289894A2 4 inverted exclamation mark -bipiperidine)-4 inverted exclamation mark -carboxamide,1 inverted exclamation mark -(3-(p-fluorobenzoyl)propyl)-( AC1L1J1T CAS_1893-33-0 GTPL92 NCGC00165864-02 PDSP2_001544 Pipamperone HCl 1'-(3-(p-Fluorobenzoyl)propyl)(1,4'-bipiperidine)-4'-carboxamide Propitan 1-(3-(p-fluorobenzoyl)propyl)-4-piperidino-isonipacotamid SR-05000001930-1 [1,4'-Bipiperidine]-4'-carboxamide, 1'-[4-(4-fluorophenyl)-4-oxobutyl]- 5-22-13-00536 (Beilstein Handbook Reference) BDBM81483 CHEBI:78549 Dipiperon Isonipecotamide, 1-(3-(p-fluorobenzoyl)propyl)-4-piperidino- NSC_4830 Pipamperona (1,4'-BIPIPERIDINE)-4'-CARBOXAMIDE, 1'-(3-(p-FLUOROBENZOYL)PROPYL)- Pipamperonum 1'-[4-(4-fluorophenyl)-4-oxobutyl]-1,4'-bipiperidine-4'-carboxamide R-3345 1-[4-(4-fluorophenyl)-4-oxobutyl]-4-piperidin-1-ylpiperidine-4-carboxamide C21H30FN3O2 D00DBO Floropipamide McN-JR-3345 P2315 Pipamperone (USAN/INN) 1 inverted exclamation mark -(3-(p-fluorobenzoyl)propyl)(1,4 inverted exclamation mark -bipiperidine)-4 inverted exclamation mark -carboxamide Piperonil 1,4'-Bipiperidine)-4'-carboxamide, 1'-(4-(4-fluorophenyl)-4-oxobutyl)- SCHEMBL2412 1893-33-0 4 inverted exclamation mark -bipiperidine)-4 inverted exclamation mark -carboxamide,1 inverted exclamation mark -(4-(4-fluorophenyl)-4-oxobutyl)-( AN-6479 CCG-213514 DB09286 HMS3264G14 NSC-759178 Pharmakon1600-01505690 pipamperone hydrochloride 1'-(3-(p-Fluorobenzoyl)propyl)-(1,4'-bipiperidine)-4'-carboxamide Propitan (Salt/Mix) 1-(4-fluorophenyl)-4-(4-piperidino-4-carbamoylpiperidino)-1-butanone UNII-5402501F0W [ Show all ]
Inchi Key	AXKPFOAXAHJUAG-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H30FN3O2/c22-18-8-6-17(7-9-18)19(26)5-4-12-24-15-10-21(11-16-24,20(23)27)25-13-2-1-3-14-25/h6-9H,1-5,10-16H2,(H2,23,27)
PubChem CID	4830
ChEMBL	N/A
IUPHAR	92
BindingDB	81483
DrugBank	DB09286
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	290.0 nM	PMID8935801	PDSP,BindingDB

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