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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Cannabinoid receptor 1
Species	Homo sapiens (Human)
Gene	CNR1
Synonym	CB1 Central cannabinoid receptor SKR6R THC receptor CB1R CANN6 CB1 receptor Neuronal cannabinoid receptor Cann7 CB-R [ Show all ]
Disease	Obesity; Diabetes Chemotherapy-induced nausea Diabetes; Obesity Drug abuse Hypertension; Diabetes; Obesity Insomnia Ischemia Lipid metabolism disorder Metabolic disorders Obesity Type 2 diabetes Schizophrenia Psychotic disorders Postherpetic neuralgia Ovarian cancer Obesity; Metabolic disorders Nicotine dependence; Obesity Neuropathic pain Cerebrovascular ischaemia Central nervous system disease Pain Anorexia Endocrine disease [ Show all ]
Length	472
Amino acid sequence	MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
UniProt	P21554
Protein Data Bank	5tjv, 5u09, 5xr8, 5xra, 6n4b, 5tgz
GPCR-HGmod model	P21554
3D structure model	This structure is from PDB ID 5tjv.
BioLiP	BL0384680, BL0364157, BL0384679, BL0384681, BL0384682, BL0384683, BL0384684, BL0440253, BL0440254,BL0440255, BL0363267, BL0361447, BL0361446
Therapeutic Target Database	T76685
ChEMBL	CHEMBL218
IUPHAR	56
DrugBank	BE0000061

Ligand

Name	362519-49-1
Molecular formula	C23H20Cl2N4O2S
IUPAC name	5-(4-chlorophenyl)-N-(4-chlorophenyl)sulfonyl-N'-methyl-4-phenyl-3,4-dihydropyrazole-2-carboximidamide
Molecular weight	487.399
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	5.3
Synonyms	R-SLV319 (+/-)-SLV 319 3-(4-Chlorophenyl)-N-[(4-Chlorophenyl)sulfonyl]-4,5-dihydro-N'-methyl-4-phenyl-1H-pyrazole-1-carboximidamide CS-6430 SCHEMBL14740149 ( inverted exclamation markA)-Ibipinabant (S)-SLV 319 AKOS024458248 HMS3650M14 MolPort-035-765-770 ( inverted exclamation markA)-SLV-319 RT-015587 (+/-)-SLV319 CTK8E8422 HY-14791A SR-01000946306 ( inverted exclamation markA)-Ibipinabant;( inverted exclamation markA)-BMS646256 BDBM29094 MolPort-042-665-745 ( inverted exclamation markA)-SLV319 3-(4-chlorophenyl)-N''''''''-(4-chlorophenylsulfonyl)-N-methyl-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboximidamide CHEMBL158784 SCHEMBL1315229 ( )-SLV 319 (S)-3-(4-chlorophenyl)-N-(4-chlorophenylsulfonyl)-N'-methyl-4-phenyl-4,5-dihydropyrazole-1-carboxamidine 4-Chloro-N-[1-[3-(4-chloro-phenyl)-4-phenyl-4,5-dihydro-pyrazol-1-yl]-1-methylamino-meth-(E)-ylidene]-benzenesulfonamide DTXSID60457819 MolPort-009-019-212 SR-01000946306-1 ( inverted exclamation markA)-SLV 319 1056AH C23H20Cl2N4O2S [ Show all ]
Inchi Key	AXJQVVLKUYCICH-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H20Cl2N4O2S/c1-26-23(28-32(30,31)20-13-11-19(25)12-14-20)29-15-21(16-5-3-2-4-6-16)22(27-29)17-7-9-18(24)10-8-17/h2-14,21H,15H2,1H3,(H,26,28)
PubChem CID	11179267
ChEMBL	CHEMBL158784
IUPHAR	N/A
BindingDB	29094
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	1.905 nM	PMID19406638	ChEMBL
IC50	1.91 nM	PMID19406638	BindingDB
IC50	22.0 nM	PMID22959249	BindingDB,ChEMBL
IC50	139.0 nM	PMID22959249	BindingDB,ChEMBL
Kd	1.995 nM	PMID20047331, PMID20137935, PMID19699640, PMID14736243	ChEMBL
Ki	3.0 nM	PMID19338356	BindingDB
Ki	4.1 nM	PMID18083560	PDSP
Ki	4.1 nM	PMID18083560	BindingDB
Ki	7.8 nM	PMID19520572	PDSP
Ki	8.0 nM	PMID18335976	PDSP,BindingDB
Ki	25.0 nM	PMID20047331, PMID19699640, PMID14736243	PDSP,BindingDB,ChEMBL
Ki	25.2 nM	PMID20137935, PMID14736243	BindingDB,ChEMBL

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