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GPCR

Name	5-hydroxytryptamine receptor 1B
Species	Cavia porcellus (Guinea pig)
Gene	HTR1B
Synonym	5-HT-1B 5-HT1B Serotonin receptor 1B
Disease	N/A for non-human GPCRs
Length	389
Amino acid sequence	MGNPEASCTPPAVLGSQTGLPHANVSAPPNNCSAPSHIYQDSIALPWKVLLVVLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAFTDLLVSILVMPISTMYTVTGRWTLGQALCDFWLSSDITCCTASIMHLCVIALDRYWAITDAVGYSAKRTPRRAAGMIALVWVFSICISLPPFFWRQAKAEEEVLDCLVNTDHVLYTVYSTGGAFYLPTLLLIALYGRIYVEARSRILKQTPNKTGKRLTRAQLITDSPGSTSSVTSINSRAPEVPCDSGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGVILGAFIVCWLPFFIISLVMPICKDACWFHMAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKCTT
UniProt	O08892
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	N/A
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	pindolol
Molecular formula	C14H20N2O2
IUPAC name	1-(1H-indol-4-yloxy)-3-(propan-2-ylamino)propan-2-ol
Molecular weight	248.326
Hydrogen bond acceptor	3
Hydrogen bond donor	3
XlogP	1.8
Synonyms	AB00052072_13 Spectrum2_001285 KBioSS_001589 Blockin L SR-01000000027-5 MCULE-7764948919 BRD-A97701745-001-05-3 Visken (TN) NCGC00015786-08 Carvisken NCGC00024925-05 CPD000059120 (.+/-.)-Pindolol P 0778 Decreten (TN) 1-(1H-Indol-4-yloxy)-3-((1-methylethyl)amino)-2-propanol Pharmakon1600-01500488 DTXSID8023476 1-(1H-Indol-4-yloxy)-3-isopropylamino-propan-2-ol(pindolol) Pindolol, >=98% (TLC), powder Glauco-Visken (TN) 2-Propanol, 1-(1H-indol-4-yloxy)-3-((1-methylethyl)amino)- Prestwick2_000090 HMS3259I07 4-(3-(Isopropylamino)-2-hydroxypropoxy)indole SAM002264631 IDI1_000837 KBio2_001589 AKOS015969756 Spectrum5_001266 LB-46 Blocklin L SW196641-3 MLS002548891 BSPBio_000020 NCGC00015786-11 CCG-39223 NCGC00261640-01 D00513 (rs)-pindolol PDSP1_000772 DL-LB 46 1-(1H-indol-4-yloxy)-3-(isopropylamino)propan-2-ol EINECS 236-867-9 1-(1H-indol-4-yloxy)-3-[(propan-2-yl)amino]propan-2-ol PINDOLOL,(-) HMS1568A22 2-Propanol, 1-(4-indolyloxy)-3-(isopropylamino)- Prindolol HMS3369E14 523P869 SCHEMBL5219 SPBio_001959 KBio3_001693 Betapindol SR-01000000027-2 LP00955 Blocklin-L (TN) Tox21_500955 NCGC00015786-06 Calvisken NCGC00015786-16 NCGC00024925-03 (+-)-Pindolol NSC757276 DB00960 1-((1H-indol-4-yl)oxy)-3-(isopropylamino)propan-2-ol Pectobloc DSSTox_GSID_23476 1-(1H-Indol-4-yloxy)-3-isopropylamino-propan-2-ol Pindolol [USAN:INN:BAN:JAN] FT-0630406 1-[1H-INDOL-4-YLOXY]-3-[ISOPROPYLAMINO]-2-PROPANOL Prestwick0_000090 HMS2091P20 3-indol-4-yloxy-1-[(methylethyl)amino]propan-2-ol Pynastin HSDB 6539 AB00052072-11 AC1L1J1N Spectrum3_000547 L000006 Blockin L (TN) SR-01000000027-7 MFCD00010530 BRD-A97701745-001-09-5 Z3376 NCGC00015786-09 Carvisken (TN) NCGC00024925-06 CS-4473 (1)-1-(1H-Indol-4-yloxy)-3-(isopropylamino)propan-2-ol P-6820 DivK1c_000837 1-(1H-Indol-4-yloxy)-3-(isopropylamino)-2-propanol Pinbetol Durapindol 1-(1H-Indol-4-yloxy)-3-[(1-methylethyl)amino]-2-propanol Pindolol, European Pharmacopoeia (EP) Reference Standard Glauco-Viskin 2-Propanol, 1-(1H-indol-4-yloxy)-3-(1-methylethyl)amino- Prestwick3_000090 HMS3262P12 5-21-03-00017 (Beilstein Handbook Reference) SBI-0050929.P004 JZQKKSLKJUAGIC-UHFFFAOYSA-N SMR000059120 KBio2_004157 AN-18448 Spectrum_001109 LB46 Blocklin L (TN) Tox21_110221 MolPort-001-792-503 BSPBio_002193 NCGC00015786-13 CCRIS 9215 (+-)-4-(2-hydroxy-3-(isopropylamino)propoxy)indole NINDS_000837 D0F2PO PDSP2_000759 DL-Pindolol 1-(1H-indol-4-yloxy)-3-(propan-2-ylamino)-propan-2-ol Pindolol (JP15/USP/INN) EINECS 244-623-8 1-(4-Indolyloxy)-3-(isopropylamino)-2-propanol Pindololum HMS1920H16 2-Propanol, 1-(indol-4-yloxy)-3-(isopropylamino)-, (+-)- Prindolol (TN) HMS3712A22 AB00052072_12 SPECTRUM1500488 KBioGR_000958 Betapindol (TN) SR-01000000027-4 LS-122385 BPBio1_000022 Visken NCGC00015786-07 Calvisken (TN) NCGC00024925-04 CHEMBL500 (+/-)-Pindolol-d7(iso-propyl-d7) Oprea1_770884 Decreten 1-(1h-indol-4-yloxy)-3-((1-methylethyl)amino)-2-propano Pectobloc (TN) DSSTox_RID_77043 1-(1H-Indol-4-yloxy)-3-isopropylamino-propan-2-ol((-)-Pindolol) Pindolol [USAN:USP:INN:BAN:JAN] Glauco-visken 13523-86-9 Prestwick1_000090 HMS2095A22 4-(2-Hydroxy-3-isopropylaminopropoxy)-indole Pynastin (TN) HY-B0982 AC1Q1QC1 Spectrum4_000479 LB 46 Blocklin ST50319990 MLS000069496 BRN 1536506 [2-hydroxy-3-(1H-indol-4-yloxy)propyl](propan-2-yl)amine NCGC00015786-10 CAS-13523-86-9 NCGC00024925-07 CTK8G2432 (R,S)-PINDOLOL PDSP1_000771 DL-4-[2-Hydroxy-3-(isopropylamino)propoxy]indole 1-(1H-Indol-4-yloxy)-3-(isopropylamino)-2-propanol # Pinbetol (TN) Durapindol (TN) 1-(1H-indol-4-yloxy)-3-[(1-methylethyl)amino]propan-2-ol Pindolol, United States Pharmacopeia (USP) Reference Standard GTPL91 2-Propanol, 1-(1H-indol-4-yloxy)-3-[(1-methylethyl)amino]- Prestwick_397 HMS3267K17 SC-25688 KBio1_000837 SPBio_001289 KBio2_006725 BDBM50019443 SR-01000000027 Lopac0_000955 Blocklin-L Tox21_110221_1 NC00467 C07445 NCGC00015786-14 NCGC00015786-20 CHEBI:8214 (+-)-lb46 NSC-757276 1-((1-Methylethyl)amino)-3-(4-indolyloxy)-2-propanol PDSP2_000760 DSSTox_CID_3476 1-(1H-indol-4-yloxy)-3-(propan-2-ylamino)propan-2-ol Pindolol (JP17/USP/INN) EU-0100955 1-(Indol-4-yloxy)-3-(isopropylamino)-2-propanol Pindololum [INN-Latin] HMS2089I21 21870-06-4 Prinodolol HMS502J19 AB00052072 [ Show all ]
Inchi Key	JZQKKSLKJUAGIC-UHFFFAOYSA-N
Inchi ID	InChI=1S/C14H20N2O2/c1-10(2)16-8-11(17)9-18-14-5-3-4-13-12(14)6-7-15-13/h3-7,10-11,15-17H,8-9H2,1-2H3
PubChem CID	4828
ChEMBL	CHEMBL500
IUPHAR	91
BindingDB	50019443
DrugBank	DB00960
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	1479.11 nM	PMID11888550	PDSP

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