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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Cholecystokinin receptor type A
Species	Rattus norvegicus (Rat)
Gene	Cckar
Synonym	CCK-A receptor CCK-AR CCK1 receptor CCK1-R cholecystokinin receptor type A cholecystokinin-1 receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	444
Amino acid sequence	MSHSPARQHLVESSRMDVVDSLLMNGSNITPPCELGLENETLFCLDQPQPSKEWQSALQILLYSIIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYFMGTSVSVSTFNLVAISLERYGAICRPLQSRVWQTKSHALKVIAATWCLSFTIMTPYPIYSNLVPFTKNNNQTANMCRFLLPSDAMQQSWQTFLLLILFLLPGIVMVVAYGLISLELYQGIKFDASQKKSAKEKKPSTGSSTRYEDSDGCYLQKSRPPRKLELQQLSSGSGGSRLNRIRSSSSAANLIAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTVSAEKHLSGTPISFILLLSYTSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGPPGVRGEVGEEEDGRTIRALLSRYSYSHMSTSAPPP
UniProt	P30551
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2871
IUPHAR	76
DrugBank	N/A

Ligand

Name	CHEMBL22630
Molecular formula	C21H16FN3O4
IUPAC name	(3S,4S)-1-(2-fluorophenyl)-5-oxo-4-(quinoline-3-carbonylamino)pyrrolidine-3-carboxylic acid
Molecular weight	393.374
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	2.5
Synonyms	BDBM50280139 (3S,4S)-1-(2-Fluoro-phenyl)-5-oxo-4-[(quinoline-3-carbonyl)-amino]-pyrrolidine-3-carboxylic acid
Inchi Key	AWUOWMONZJSVLQ-KSSFIOAISA-N
Inchi ID	InChI=1S/C21H16FN3O4/c22-15-6-2-4-8-17(15)25-11-14(21(28)29)18(20(25)27)24-19(26)13-9-12-5-1-3-7-16(12)23-10-13/h1-10,14,18H,11H2,(H,24,26)(H,28,29)/t14-,18-/m0/s1
PubChem CID	44458114
ChEMBL	CHEMBL22630
IUPHAR	N/A
BindingDB	50280139
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	170.0 nM	, Bioorg. Med. Chem. Lett., (1992) 2:10:1251	BindingDB,ChEMBL

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