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Name | G-protein coupled receptor 4 |
---|---|
Species | Homo sapiens (Human) |
Gene | GPR4 |
Synonym | G-protein coupled receptor 19 GPR19 GPR4 |
Disease | N/A |
Length | 362 |
Amino acid sequence | MGNHTWEGCHVDSRVDHLFPPSLYIFVIGVGLPTNCLALWAAYRQVQQRNELGVYLMNLSIADLLYICTLPLWVDYFLHHDNWIHGPGSCKLFGFIFYTNIYISIAFLCCISVDRYLAVAHPLRFARLRRVKTAVAVSSVVWATELGANSAPLFHDELFRDRYNHTFCFEKFPMEGWVAWMNLYRVFVGFLFPWALMLLSYRGILRAVRGSVSTERQEKAKIKRLALSLIAIVLVCFAPYHVLLLSRSAIYLGRPWDCGFEERVFSAYHSSLAFTSLNCVADPILYCLVNEGARSDVAKALHNLLRFLASDKPQEMANASLTLETPLTSKRNSTAKAMTGSWAATPPSQGDQVQLKMLPPAQ |
UniProt | P46093 |
Protein Data Bank | N/A |
GPCR-HGmod model | P46093 |
3D structure model | This predicted structure model is from GPCR-EXP P46093. |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3638324 |
IUPHAR | N/A |
DrugBank | N/A |
Name | CHEMBL3675725 |
---|---|
Molecular formula | C28H38N6O2 |
IUPAC name | (2S)-1-[4-[(E)-3-[4-[(2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl]phenyl]prop-2-enyl]piperazin-1-yl]-3-hydroxy-2-(methylamino)propan-1-one |
Molecular weight | 490.652 |
Hydrogen bond acceptor | 6 |
Hydrogen bond donor | 2 |
XlogP | 2.6 |
Synonyms | US8748435, 15 BDBM123490 SCHEMBL12802890 SCHEMBL12802896 |
Inchi Key | ACIIISFLWFQWJG-HWMYGDGXSA-N |
Inchi ID | InChI=1S/C28H38N6O2/c1-5-25-24(27-30-20(2)17-21(3)34(27)31-25)18-23-10-8-22(9-11-23)7-6-12-32-13-15-33(16-14-32)28(36)26(19-35)29-4/h6-11,17,26,29,35H,5,12-16,18-19H2,1-4H3/b7-6+/t26-/m0/s1 |
PubChem CID | 68379293 |
ChEMBL | CHEMBL3675725 |
IUPHAR | N/A |
BindingDB | 123490 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 51.0 nM | , None | BindingDB,ChEMBL |
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