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Name | 5-hydroxytryptamine receptor 2A |
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Species | Rattus norvegicus (Rat) |
Gene | Htr2a |
Synonym | serotonin 5HT-2 receptor 5Ht-2 'D' receptor 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 5-HT2A receptor [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 471 |
Amino acid sequence | MEILCEDNISLSSIPNSLMQLGDGPRLYHNDFNSRDANTSEASNWTIDAENRTNLSCEGYLPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAIWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPALAYKSSQLQVGQKKNSQEDAEQTVDDCSMVTLGKQQSEENCTDNIETVNEKVSCV |
UniProt | P14842 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL322 |
IUPHAR | 6 |
DrugBank | N/A |
Name | CHEMBL3216071 |
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Molecular formula | C23H25Cl2N5O |
IUPAC name | 3-[2-(4-phenylpiperazin-1-yl)ethyl]pyrimido[5,4-c]quinolin-4-one;dihydrochloride |
Molecular weight | 458.387 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 2 |
XlogP | None |
Synonyms | N/A |
Inchi Key | AVZNYSLSIWRUBV-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C23H23N5O.2ClH/c29-23-20-16-24-21-9-5-4-8-19(21)22(20)25-17-28(23)15-12-26-10-13-27(14-11-26)18-6-2-1-3-7-18;;/h1-9,16-17H,10-15H2;2*1H |
PubChem CID | 90664584 |
ChEMBL | CHEMBL3216071 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | Partition coefficient log P of this ligand is not available. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Inhibition | 26.0 % | PMID21601317 | ChEMBL |
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