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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Melanin-concentrating hormone receptor 1
Species	Homo sapiens (Human)
Gene	MCHR1
Synonym	SLC-1 Somatostatin receptor-like protein MCHR-1 MCHR MCH1R MCH1 receptor MCH-R1 MCH-1R MCH receptor 1 GPR24 G-protein coupled receptor 24 G protein-coupled receptor 24 [ Show all ]
Disease	Obesity Obesity; Anxiety; Depression
Length	422
Amino acid sequence	MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
UniProt	Q99705
Protein Data Bank	N/A
GPCR-HGmod model	Q99705
3D structure model	This predicted structure model is from GPCR-EXP Q99705.
BioLiP	N/A
Therapeutic Target Database	T09572
ChEMBL	CHEMBL344
IUPHAR	280
DrugBank	BE0003478

Ligand

Name	CHEMBL540930
Molecular formula	C31H29ClF4N4O2
IUPAC name	N-[(5-chloro-6-oxo-1H-pyridin-3-yl)-(4-fluorophenyl)methyl]-2-[1-[[1-[4-(trifluoromethyl)phenyl]pyrrol-3-yl]methyl]piperidin-4-yl]acetamide
Molecular weight	601.043
Hydrogen bond acceptor	7
Hydrogen bond donor	2
XlogP	5.0
Synonyms	BDBM50296043 N-((5-chloro-6-oxo-1,6-dihydropyridin-3-yl)(4-fluorophenyl)methyl)-2-(1-((1-(4-(trifluoromethyl)phenyl)-1H-pyrrol-3-yl)methyl)piperidin-4-yl)acetamide
Inchi Key	ACHAGBFZZOHGJZ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C31H29ClF4N4O2/c32-27-16-23(17-37-30(27)42)29(22-1-5-25(33)6-2-22)38-28(41)15-20-9-12-39(13-10-20)18-21-11-14-40(19-21)26-7-3-24(4-8-26)31(34,35)36/h1-8,11,14,16-17,19-20,29H,9-10,12-13,15,18H2,(H,37,42)(H,38,41)
PubChem CID	11599973
ChEMBL	CHEMBL540930
IUPHAR	N/A
BindingDB	50296043
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
IC50	6.0 nM	PMID19500979	BindingDB,ChEMBL
IC50	21.0 nM	PMID19500979	BindingDB,ChEMBL

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