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GPCR

NameG-protein coupled receptor 4
SpeciesHomo sapiens (Human)
GeneGPR4
SynonymG-protein coupled receptor 19
GPR19
GPR4
DiseaseN/A
Length362
Amino acid sequenceMGNHTWEGCHVDSRVDHLFPPSLYIFVIGVGLPTNCLALWAAYRQVQQRNELGVYLMNLSIADLLYICTLPLWVDYFLHHDNWIHGPGSCKLFGFIFYTNIYISIAFLCCISVDRYLAVAHPLRFARLRRVKTAVAVSSVVWATELGANSAPLFHDELFRDRYNHTFCFEKFPMEGWVAWMNLYRVFVGFLFPWALMLLSYRGILRAVRGSVSTERQEKAKIKRLALSLIAIVLVCFAPYHVLLLSRSAIYLGRPWDCGFEERVFSAYHSSLAFTSLNCVADPILYCLVNEGARSDVAKALHNLLRFLASDKPQEMANASLTLETPLTSKRNSTAKAMTGSWAATPPSQGDQVQLKMLPPAQ
UniProtP46093
Protein Data BankN/A
GPCR-HGmod modelP46093
3D structure modelThis predicted structure model is from GPCR-EXP P46093.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3638324
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL3670933
Molecular formulaC30H42N4O3
IUPAC nametert-butyl 4-[3-[4-[(2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl]phenyl]propyl]-4-hydroxypiperidine-1-carboxylate
Molecular weight506.691
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogP5.4
SynonymsBDBM123479
SCHEMBL12802588
US8748435, 4
Inchi KeyJNYMFWUBRIAGIH-UHFFFAOYSA-N
Inchi IDInChI=1S/C30H42N4O3/c1-7-26-25(27-31-21(2)19-22(3)34(27)32-26)20-24-12-10-23(11-13-24)9-8-14-30(36)15-17-33(18-16-30)28(35)37-29(4,5)6/h10-13,19,36H,7-9,14-18,20H2,1-6H3
PubChem CID68379124
ChEMBLCHEMBL3670933
IUPHARN/A
BindingDB123479
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC5047.0 nM, NoneBindingDB,ChEMBL

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