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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Galanin receptor type 3
Species	Homo sapiens (Human)
Gene	GALR3
Synonym	GAL3-R Galnr3 GALR-3 GALR3 GAL3 receptor
Disease	Cognitive disorders
Length	368
Amino acid sequence	MADAQNISLDSPGSVGAVAVPVVFALIFLLGTVGNGLVLAVLLQPGPSAWQEPGSTTDLFILNLAVADLCFILCCVPFQATIYTLDAWLFGALVCKAVHLLIYLTMYASSFTLAAVSVDRYLAVRHPLRSRALRTPRNARAAVGLVWLLAALFSAPYLSYYGTVRYGALELCVPAWEDARRRALDVATFAAGYLLPVAVVSLAYGRTLRFLWAAVGPAGAAAAEARRRATGRAGRAMLAVAALYALCWGPHHALILCFWYGRFAFSPATYACRLASHCLAYANSCLNPLVYALASRHFRARFRRLWPCGRRRRHRARRALRRVRPASSGPPGCPGDARPSGRLLAGGGQGPEPREGPVHGGEAARGPE
UniProt	O60755
Protein Data Bank	N/A
GPCR-HGmod model	O60755
3D structure model	This predicted structure model is from GPCR-EXP O60755.
BioLiP	N/A
Therapeutic Target Database	T98494
ChEMBL	CHEMBL2731
IUPHAR	245
DrugBank	N/A

Ligand

Name	MLS003230991
Molecular formula	C23H15F3N2O
IUPAC name	2-(furan-2-yl)-3-[[2-(trifluoromethyl)phenyl]methyl]imidazo[2,1-a]isoquinoline
Molecular weight	392.381
Hydrogen bond acceptor	5
Hydrogen bond donor	0
XlogP	6.6
Synonyms	2-(furan-2-yl)-3-[[2-(trifluoromethyl)phenyl]methyl]imidazo[2,1-a]isoquinoline 2-(2-furanyl)-3-[[2-(trifluoromethyl)phenyl]methyl]imidazo[2,1-a]isoquinoline CHEMBL2361231 2-(2-furyl)-3-[2-(trifluoromethyl)benzyl]imidaz[2,1-a]isoquinoline SMR001913556 BDBM97187 cid_51360001 [ Show all ]
Inchi Key	JGUBEXLRWYVZIG-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H15F3N2O/c24-23(25,26)18-9-4-2-7-16(18)14-19-21(20-10-5-13-29-20)27-22-17-8-3-1-6-15(17)11-12-28(19)22/h1-13H,14H2
PubChem CID	51360001
ChEMBL	CHEMBL2361231
IUPHAR	N/A
BindingDB	97187
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	13043.0 nM	, PubChem BioAssay data set	BindingDB,ChEMBL

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