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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Glucose-dependent insulinotropic receptor
Species	Homo sapiens (Human)
Gene	GPR119
Synonym	GPCR2 GPR119 G-protein coupled receptor 2 G-protein coupled receptor 119 G protein-coupled receptor 119 glucose-dependent insulinotropic receptor [ Show all ]
Disease	Type 2 diabetes Diabetes Peripheral arterial disease; Type 2 diabetes Non-insulin dependent diabetes Gastric cancer; Type 2 diabetes
Length	335
Amino acid sequence	MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
UniProt	Q8TDV5
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDV5
3D structure model	This predicted structure model is from GPCR-EXP Q8TDV5.
BioLiP	N/A
Therapeutic Target Database	T93788
ChEMBL	CHEMBL5652
IUPHAR	126
DrugBank	N/A

Ligand

Name	CHEMBL1778152
Molecular formula	C21H25F3N4O4S
IUPAC name	(1S,5S)-3-[5-methyl-6-(2-methylpyridin-3-yl)oxypyrimidin-4-yl]oxy-8-(3,3,3-trifluoropropylsulfonyl)-8-azabicyclo[3.2.1]octane
Molecular weight	486.51
Hydrogen bond acceptor	11
Hydrogen bond donor	0
XlogP	4.0
Synonyms	BDBM50344497 (1S,5S)-3-(5-methyl-6-(2-methylpyridin-3-yloxy)pyrimidin-4-yloxy)-8-(3,3,3-trifluoropropylsulfonyl)-8-azabicyclo[3.2.1]octane SCHEMBL12275425
Inchi Key	JEQHGHRMOQYJDU-HOTGVXAUSA-N
Inchi ID	InChI=1S/C21H25F3N4O4S/c1-13-19(26-12-27-20(13)32-18-4-3-8-25-14(18)2)31-17-10-15-5-6-16(11-17)28(15)33(29,30)9-7-21(22,23)24/h3-4,8,12,15-17H,5-7,9-11H2,1-2H3/t15-,16-/m0/s1
PubChem CID	54583651
ChEMBL	N/A
IUPHAR	N/A
BindingDB	50344497
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 10 hydrogen bond acceptor.

Experimental Data

Parameter	Value	Reference	Database source
EC50	112.0 nM	PMID21536438	BindingDB

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