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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Galanin receptor type 3
Species	Homo sapiens (Human)
Gene	GALR3
Synonym	GAL3-R Galnr3 GALR-3 GALR3 GAL3 receptor
Disease	Cognitive disorders
Length	368
Amino acid sequence	MADAQNISLDSPGSVGAVAVPVVFALIFLLGTVGNGLVLAVLLQPGPSAWQEPGSTTDLFILNLAVADLCFILCCVPFQATIYTLDAWLFGALVCKAVHLLIYLTMYASSFTLAAVSVDRYLAVRHPLRSRALRTPRNARAAVGLVWLLAALFSAPYLSYYGTVRYGALELCVPAWEDARRRALDVATFAAGYLLPVAVVSLAYGRTLRFLWAAVGPAGAAAAEARRRATGRAGRAMLAVAALYALCWGPHHALILCFWYGRFAFSPATYACRLASHCLAYANSCLNPLVYALASRHFRARFRRLWPCGRRRRHRARRALRRVRPASSGPPGCPGDARPSGRLLAGGGQGPEPREGPVHGGEAARGPE
UniProt	O60755
Protein Data Bank	N/A
GPCR-HGmod model	O60755
3D structure model	This predicted structure model is from GPCR-EXP O60755.
BioLiP	N/A
Therapeutic Target Database	T98494
ChEMBL	CHEMBL2731
IUPHAR	245
DrugBank	N/A

Ligand

Name	Bio3H4
Molecular formula	C13H7F3N6
IUPAC name	2-[[4-[3-(trifluoromethyl)pyrazol-1-yl]phenyl]hydrazinylidene]propanedinitrile
Molecular weight	304.236
Hydrogen bond acceptor	8
Hydrogen bond donor	1
XlogP	3.6
Synonyms	HMS1662F10 REGID_for_CID_2809268 MCULE-6792425940 AC1MDCT3 ZINC117399 CHEMBL1384771 MolPort-002-899-834 [ Show all ]
Inchi Key	IXSWFOKLLLVEJO-UHFFFAOYSA-N
Inchi ID	InChI=1S/C13H7F3N6/c14-13(15,16)12-5-6-22(21-12)11-3-1-9(2-4-11)19-20-10(7-17)8-18/h1-6,19H
PubChem CID	2809268
ChEMBL	CHEMBL1384771
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<1109.0 nM	PubChem BioAssay data set	ChEMBL

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