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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	C-C chemokine receptor type 2
Species	Mus musculus (Mouse)
Gene	Ccr2
Synonym	JE/FIC receptor CKR2 chemokine receptor CCR2 chemokine (C-C motif) receptor 2 CD192 CCR2B CCR2A CCR2 CCR-2 CC-CKR-2 CC CKR2 C-C CKR-2 MCP-1 receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	373
Amino acid sequence	MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL
UniProt	P51683
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5412
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL1171586
Molecular formula	C20H13ClF3NO5S
IUPAC name	2-[2-[(4-chlorophenyl)sulfonylamino]-4-(trifluoromethyl)phenoxy]benzoic acid
Molecular weight	471.831
Hydrogen bond acceptor	9
Hydrogen bond donor	2
XlogP	5.0
Synonyms	BDBM50416302 IWSNTIDXIKYXSU-UHFFFAOYSA-N 2-[2-(4-chlorophenylsulfonamido)-4-(trifluoromethyl)phenoxy]benzoic acid SCHEMBL5665185
Inchi Key	IWSNTIDXIKYXSU-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H13ClF3NO5S/c21-13-6-8-14(9-7-13)31(28,29)25-16-11-12(20(22,23)24)5-10-18(16)30-17-4-2-1-3-15(17)19(26)27/h1-11,25H,(H,26,27)
PubChem CID	19430534
ChEMBL	CHEMBL1171586
IUPHAR	N/A
BindingDB	50416302
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	1584.89 nM	PMID20627722	BindingDB,ChEMBL

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