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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Gonadotropin-releasing hormone receptor
Species	Rattus norvegicus (Rat)
Gene	Gnrhr
Synonym	luteinizing hormone-releasing hormone (LHRH) receptor luliberin receptor LHRHR LHRH receptor GNRHR1 GnRHR GnRH1 receptor GnRH-R GnRH receptor GnRH I receptor Type I GnRHR [ Show all ]
Disease	N/A for non-human GPCRs
Length	327
Amino acid sequence	MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL
UniProt	P30969
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3066
IUPHAR	256
DrugBank	N/A

Ligand

Name	CHEMBL48763
Molecular formula	C35H46N4O3S
IUPAC name	2-(3,5-dimethylphenyl)-N-ethyl-3-[2-[4-[4-(methanesulfonamido)phenyl]butylamino]ethyl]-N-propan-2-yl-1H-indole-5-carboxamide
Molecular weight	602.838
Hydrogen bond acceptor	5
Hydrogen bond donor	3
XlogP	6.5
Synonyms	BDBM50101183 N-Isopropyl-N-ethyl-2-(3,5-dimethylphenyl)-3-[2-[4-[4-(methylsulfonylamino)phenyl]butylamino]ethyl]-1H-indole-5-carboxamide 2-(3,5-Dimethyl-phenyl)-3-{2-[4-(4-methanesulfonylamino-phenyl)-butylamino]-ethyl}-1H-indole-5-carboxylic acid ethyl-isopropyl-amide
Inchi Key	ATFRLQACYBGIPP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C35H46N4O3S/c1-7-39(24(2)3)35(40)28-13-16-33-32(23-28)31(34(37-33)29-21-25(4)20-26(5)22-29)17-19-36-18-9-8-10-27-11-14-30(15-12-27)38-43(6,41)42/h11-16,20-24,36-38H,7-10,17-19H2,1-6H3
PubChem CID	44293194
ChEMBL	CHEMBL48763
IUPHAR	N/A
BindingDB	50101183
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	3.0 nM	PMID11425546	BindingDB,ChEMBL
IC50	120.0 nM	PMID11425546	BindingDB,ChEMBL

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