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GPCR

Name	D(2) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD2
Synonym	dopamine receptor 2 Dopamine D2 receptor D2R D2A and D_2B D2(415) and D₂₍₄₄₄₎ D2 receptor [ Show all ]
Disease	Substance dependence Major depressive disorder Maintain blood pressure in hypotensive states Insomnia Inflammatory disease Inflammatory bowel disease Idiopathic thrombocytopenic purpura Hypertension; Angina pectoris Hypertension Hyperprolactinemia Huntington's disease Glaucoma Gastrointestinal problems Malignant phaeochromocytoma; Benign prostatic hypertrophy; Malignant essential hypertension Migraine headaches Nasal congestion Sexual dysfunction Schizophrenia; Schizoaffective disorders Schizophrenia; Bipolar disorder Schizophrenia Psychotic disorders Psychosis Postpartum haemorrhage Peripheral vasoconstriction; Pulmonary hypertension Parkinson's disease Pain; Inflammatory diseases Ophthalmic disease Non-small cell lung cancer Nausea; Vomiting Fibrosis False perceptions; Bipolar disorder Emesis Chronic obstructive pulmonary disease Cerebrovascular ischaemia Cardiotonic Cardiac failure Bacterial infections Breast cancer Bipolar disorder; Schizophrenia Bipolar disorder Corneal vascularity; Hyperaemia; Itching Asthma; Bronchitis Anxiety disorder Carcinoid syndrome; Acromegaly Advanced stage Parkinson's disease Dermal necrosis Depressive fatigue Alcohol use disorders Allergy Alzheimer disease Hypotension [ Show all ]
Length	443
Amino acid sequence	MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
UniProt	P14416
Protein Data Bank	6cm4, 6c38
GPCR-HGmod model	P14416
3D structure model	This structure is from PDB ID 6cm4.
BioLiP	BL0408379, BL0403379
Therapeutic Target Database	T67162
ChEMBL	CHEMBL217
IUPHAR	215
DrugBank	BE0000756

Ligand

Name	CHEMBL26998
Molecular formula	C16H25NO
IUPAC name	(7R)-7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol
Molecular weight	247.382
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	4.1
Synonyms	(r)-8-hydroxy-2-(di-n-propyl-amino)tetralin AC1O7G3K NCGC00015493-01 R-(+)-7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol 7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol BRD-K59765110-004-03-8 FT-0641759 NCGC00024635-01 Tocris-1080 (8-Hydroxyl-1,2,3,4-tetrahydro-naphthalen-2-yl)-dipropyl-amine 8-Hydroxy-2-(di-n-propylamino)tetralin, (R)-Isomer CHEBI:103846 Lopac0_000638 PDSP1_001710 (R)-8-OH-DPAT AKOS015966329 CTK3E5783 NCGC00015493-02 SCHEMBL1682347 UNII-IWS1724PX6 component ASXGJMSKWNBENU-CQSZACIVSA-N ((R)-8-Hydroxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-dipropyl-ammonium 7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol ((R)-OH-DPAT) C-19929 Lopac-H-140 NCGC00024986-01 (R)-7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol 80300-09-0 LS-177548 PDSP2_001693 BDBM50016777 DTXSID00424964 NCGC00015493-03 Tocris-0529 ZINC3870312 (7R)-7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol 7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol(8-OH-DPAT) CCG-204725 Lopac-H-8250 NCGC00024986-03 [ Show all ]
Inchi Key	ASXGJMSKWNBENU-CQSZACIVSA-N
Inchi ID	InChI=1S/C16H25NO/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14/h5-7,14,18H,3-4,8-12H2,1-2H3/t14-/m1/s1
PubChem CID	6603866
ChEMBL	CHEMBL26998
IUPHAR	N/A
BindingDB	50016777
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<413.0 nM	PMID7731017	BindingDB,ChEMBL
Ki	90.0 nM	PMID7731017	BindingDB,ChEMBL
Ki	93.0 nM	PMID8101876	BindingDB,ChEMBL
Ki	819.0 nM	PMID10753471	BindingDB
Ki	819.0 nM	PMID10753471	ChEMBL

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