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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 1A
Species	Mus musculus (Mouse)
Gene	Htr1a
Synonym	5-HT-1A Gpcr18 ADRBRL1 ADRB2RL1 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 5-HT1A receptor 5-HT1A Serotonin receptor 1A [ Show all ]
Disease	N/A for non-human GPCRs
Length	421
Amino acid sequence	MDMFSLGQGNNTTTSLEPFGTGGNDTGLSNVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSNPNECTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKKGAGTSFGTSSAPPPKKSLNGQPGSGDCRRSAENRAVGTPCANGAVRQGEDDATLEVIEVHRVGNSKGHLPLPSESGATSYVPACLERKNERTAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPELLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCR
UniProt	Q64264
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3737
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL26998
Molecular formula	C16H25NO
IUPAC name	(7R)-7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol
Molecular weight	247.382
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	4.1
Synonyms	AKOS015966329 CTK3E5783 NCGC00015493-02 SCHEMBL1682347 (R)-8-OH-DPAT 7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol ((R)-OH-DPAT) C-19929 Lopac-H-140 NCGC00024986-01 UNII-IWS1724PX6 component ASXGJMSKWNBENU-CQSZACIVSA-N ((R)-8-Hydroxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-dipropyl-ammonium 80300-09-0 LS-177548 PDSP2_001693 (R)-7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol BDBM50016777 DTXSID00424964 NCGC00015493-03 Tocris-0529 7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol(8-OH-DPAT) CCG-204725 Lopac-H-8250 NCGC00024986-03 ZINC3870312 (7R)-7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol AC1O7G3K NCGC00015493-01 R-(+)-7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol (r)-8-hydroxy-2-(di-n-propyl-amino)tetralin 7-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol BRD-K59765110-004-03-8 FT-0641759 NCGC00024635-01 Tocris-1080 8-Hydroxy-2-(di-n-propylamino)tetralin, (R)-Isomer CHEBI:103846 Lopac0_000638 PDSP1_001710 (8-Hydroxyl-1,2,3,4-tetrahydro-naphthalen-2-yl)-dipropyl-amine [ Show all ]
Inchi Key	ASXGJMSKWNBENU-CQSZACIVSA-N
Inchi ID	InChI=1S/C16H25NO/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14/h5-7,14,18H,3-4,8-12H2,1-2H3/t14-/m1/s1
PubChem CID	6603866
ChEMBL	CHEMBL26998
IUPHAR	N/A
BindingDB	50016777
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	0.5 nM	PMID7731017	ChEMBL
Ki	0.5 nM	PMID7731017	BindingDB

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