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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Mu-type opioid receptor
Species	Rattus norvegicus (Rat)
Gene	Oprm1
Synonym	Opioid receptor B opioid receptor OP3 mu receptor MOR-1 MOPr MOP M-OR-1 opioid receptor, mu 1 [ Show all ]
Disease	N/A for non-human GPCRs
Length	398
Amino acid sequence	MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
UniProt	P33535
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL270
IUPHAR	319
DrugBank	N/A

Ligand

Name	Hydromorphine
Molecular formula	C17H21NO3
IUPAC name	3-methyl-2,4,4a,5,6,7,7a,13-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol
Molecular weight	287.359
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	1.8
Synonyms	FT-0667072 Morphine, 7,8-dihydro- WLN: T B6566 B6/CO 4ABBC R BX HO PN GHT&&TTJ FQ JQ P1 CAS_509-60-4 L000955 NSC117865 .alpha.-Dihydromorphine DIHYDROBROMORPHINE Morphinan-3,6-diol, 4,5-epoxy-17-methyl-, (5.alpha.,6.alpha.)- Paramorphan AC1L6SLS Morphine, dihydro- (5.alpha.,6.alpha.)-4,5-Epoxy-17-methylmorphinan-3,6-diol Morphinan-3, 4,5-epoxy-17-methyl-, (5.alpha.,6.alpha.)- NSC_273032 6.alpha.-Hydromorphol Dihydromorfin Morphinan-3,6.alpha.-diol, 4,5.alpha.-epoxy-17-methyl- SCHEMBL6123637 BDBM86518 IJVCSMSMFSCRME-UHFFFAOYSA-N NSC-117865 CHEMBL608541 Morphinan-3, 4,5.alpha.-epoxy-17-methyl- Paramorfan [ Show all ]
Inchi Key	IJVCSMSMFSCRME-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H21NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2,4,10-11,13,16,19-20H,3,5-8H2,1H3
PubChem CID	273032
ChEMBL	CHEMBL608541
IUPHAR	N/A
BindingDB	86518
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Kp	13.5 -	PMID2831361	ChEMBL
KT	19.0 -	PMID2831361	ChEMBL

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