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GLASS

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GPCR

Name	Galanin receptor type 3
Species	Homo sapiens (Human)
Gene	GALR3
Synonym	GAL3-R Galnr3 GALR-3 GALR3 GAL3 receptor
Disease	Cognitive disorders
Length	368
Amino acid sequence	MADAQNISLDSPGSVGAVAVPVVFALIFLLGTVGNGLVLAVLLQPGPSAWQEPGSTTDLFILNLAVADLCFILCCVPFQATIYTLDAWLFGALVCKAVHLLIYLTMYASSFTLAAVSVDRYLAVRHPLRSRALRTPRNARAAVGLVWLLAALFSAPYLSYYGTVRYGALELCVPAWEDARRRALDVATFAAGYLLPVAVVSLAYGRTLRFLWAAVGPAGAAAAEARRRATGRAGRAMLAVAALYALCWGPHHALILCFWYGRFAFSPATYACRLASHCLAYANSCLNPLVYALASRHFRARFRRLWPCGRRRRHRARRALRRVRPASSGPPGCPGDARPSGRLLAGGGQGPEPREGPVHGGEAARGPE
UniProt	O60755
Protein Data Bank	N/A
GPCR-HGmod model	O60755
3D structure model	This predicted structure model is from GPCR-EXP O60755.
BioLiP	N/A
Therapeutic Target Database	T98494
ChEMBL	CHEMBL2731
IUPHAR	245
DrugBank	N/A

Ligand

Name	MLS000391427
Molecular formula	C21H18Cl2N2O3S
IUPAC name	N-[4-(2,4-dichlorophenyl)-1,3-thiazol-2-yl]-4-(oxolan-2-ylmethoxy)benzamide
Molecular weight	449.346
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	5.4
Synonyms	756856-52-7 HMS2623N10 N-[4-(2,4-dichlorophenyl)thiazol-2-yl]-4-(tetrahydrofurfuryloxy)benzamide AKOS034047684 MLS003914913 SR-01000716198-2 CHEMBL1545848 N-[4-(2,4-dichlorophenyl)-1,3-thiazol-2-yl]-4-[(oxolan-2-yl)methoxy]benzamide MCULE-3793008490 SMR000260463 BDBM97088 MolPort-005-856-420 Z28352384 cid_4544702 N-[4-(2,4-dichlorophenyl)-2-thiazolyl]-4-(2-oxolanylmethoxy)benzamide AC1ND5OR SR-01000716198 N-[4-(2,4-dichlorophenyl)-1,3-thiazol-2-yl]-4-(oxolan-2-ylmethoxy)benzamide [ Show all ]
Inchi Key	IIWNGLGBKYAGTD-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H18Cl2N2O3S/c22-14-5-8-17(18(23)10-14)19-12-29-21(24-19)25-20(26)13-3-6-15(7-4-13)28-11-16-2-1-9-27-16/h3-8,10,12,16H,1-2,9,11H2,(H,24,25,26)
PubChem CID	4544702
ChEMBL	CHEMBL1545848
IUPHAR	N/A
BindingDB	97088
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	1072.0 nM	, PubChem BioAssay data set	BindingDB,ChEMBL

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