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GLASS

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GPCR

Name	Galanin receptor type 3
Species	Homo sapiens (Human)
Gene	GALR3
Synonym	GAL3-R Galnr3 GALR-3 GALR3 GAL3 receptor
Disease	Cognitive disorders
Length	368
Amino acid sequence	MADAQNISLDSPGSVGAVAVPVVFALIFLLGTVGNGLVLAVLLQPGPSAWQEPGSTTDLFILNLAVADLCFILCCVPFQATIYTLDAWLFGALVCKAVHLLIYLTMYASSFTLAAVSVDRYLAVRHPLRSRALRTPRNARAAVGLVWLLAALFSAPYLSYYGTVRYGALELCVPAWEDARRRALDVATFAAGYLLPVAVVSLAYGRTLRFLWAAVGPAGAAAAEARRRATGRAGRAMLAVAALYALCWGPHHALILCFWYGRFAFSPATYACRLASHCLAYANSCLNPLVYALASRHFRARFRRLWPCGRRRRHRARRALRRVRPASSGPPGCPGDARPSGRLLAGGGQGPEPREGPVHGGEAARGPE
UniProt	O60755
Protein Data Bank	N/A
GPCR-HGmod model	O60755
3D structure model	This predicted structure model is from GPCR-EXP O60755.
BioLiP	N/A
Therapeutic Target Database	T98494
ChEMBL	CHEMBL2731
IUPHAR	245
DrugBank	N/A

Ligand

Name	BAS 00918756
Molecular formula	C7H11ClN4O2S
IUPAC name	4-(2-chloroethylamino)-N-(2-hydroxyethyl)-1,2,5-thiadiazole-3-carboxamide
Molecular weight	250.701
Hydrogen bond acceptor	6
Hydrogen bond donor	3
XlogP	0.8
Synonyms	cid_548479 SR-01000317533-1 MCULE-9614737208 ZINC2239867 1,2,5-Thiadiazole-3-carboxamide, 4-[(2-chloroethyl)amino]-N-(2-hydroxyethyl)- SMR000285005 4-[(2-Chloroethyl)amino]-N-(2-hydroxyethyl)-1,2,5-thiadiazole-3-carboxamide HMS2643J24 ST50338248 AC1LC5WS BDBM97102 MLS000678378 {4-[(2-chloroethyl)amino](1,2,5-thiadiazol-3-yl)}-N-(2-hydroxyethyl)carboxamid e 147194-45-4 CHEMBL1603519 SR-01000317533 4-[(2-Chloroethyl)amino]-N-(2-hydroxyethyl)-1,2,5-thiadiazole-3-carboxamide # IFFHKZADUJHGLP-UHFFFAOYSA-N STK368221 AKOS000678496 C7H11ClN4O2S MolPort-001-887-047 4-(2-chloroethylamino)-N-(2-hydroxyethyl)-1,2,5-thiadiazole-3-carboxamide [ Show all ]
Inchi Key	IFFHKZADUJHGLP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C7H11ClN4O2S/c8-1-2-9-6-5(11-15-12-6)7(14)10-3-4-13/h13H,1-4H2,(H,9,12)(H,10,14)
PubChem CID	548479
ChEMBL	CHEMBL1603519
IUPHAR	N/A
BindingDB	97102
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<29907.0 nM	, PubChem BioAssay data set	BindingDB,ChEMBL

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