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Name | Neuropeptide Y receptor type 2 |
---|---|
Species | Homo sapiens (Human) |
Gene | NPY2R |
Synonym | NPY2-R NPY-Y2 receptor neuropeptide Y receptor type 2 Y2 receptor |
Disease | Diabetes Metabolic disorders Obesity |
Length | 381 |
Amino acid sequence | MGPIGAEADENQTVEEMKVEQYGPQTTPRGELVPDPEPELIDSTKLIEVQVVLILAYCSIILLGVIGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHLESKISKRISFLIIGLAWGISALLASPLAIFREYSLIEIIPDFEIVACTEKWPGEEKSIYGTVYSLSSLLILYVLPLGIISFSYTRIWSKLKNHVSPGAANDHYHQRRQKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSQVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCEQRLDAIHSEVSVTFKAKKNLEVRKNSGPNDSFTEATNV |
UniProt | P49146 |
Protein Data Bank | N/A |
GPCR-HGmod model | P49146 |
3D structure model | This predicted structure model is from GPCR-EXP P49146. |
BioLiP | N/A |
Therapeutic Target Database | T10670 |
ChEMBL | CHEMBL4018 |
IUPHAR | 306 |
DrugBank | BE0002419 |
Name | BDBM50442573 |
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Molecular formula | C86H120N22O16 |
IUPAC name | N-[2-[2-aminoethyl-[2-[[4-[2-[2-[2-[[N-[(4R)-5-[[4-[(carbamoylamino)methyl]phenyl]methylamino]-4-[(2,2-diphenylacetyl)amino]-5-oxopentyl]carbamimidoyl]carbamoylamino]ethoxy]ethoxy]ethylamino]-4-oxobutanoyl]amino]ethyl]amino]ethyl]-N'-[2-[2-[2-[[N'-[(4R)-5-[[4-[(carbamoylamino)methyl]phenyl]methylamino]-4-[(2,2-diphenylacetyl)amino]-5-oxopentyl]carbamimidoyl]carbamoylamino]ethoxy]ethoxy]ethyl]butanediamide |
Molecular weight | 1718.04 |
Hydrogen bond acceptor | 20 |
Hydrogen bond donor | 20 |
XlogP | -0.4 |
Synonyms | N/A |
Inchi Key | IEUJAGBMWVPDJC-FAECOVEHSA-N |
Inchi ID | InChI=1S/C86H120N22O16/c87-37-46-108(47-40-92-71(109)33-35-73(111)94-42-49-121-53-55-123-51-44-98-85(119)106-81(88)96-38-13-23-69(77(113)100-57-61-25-29-63(30-26-61)59-102-83(90)117)104-79(115)75(65-15-5-1-6-16-65)66-17-7-2-8-18-66)48-41-93-72(110)34-36-74(112)95-43-50-122-54-56-124-52-45-99-86(120)107-82(89)97-39-14-24-70(78(114)101-58-62-27-31-64(32-28-62)60-103-84(91)118)105-80(116)76(67-19-9-3-10-20-67)68-21-11-4-12-22-68/h1-12,15-22,25-32,69-70,75-76H,13-14,23-24,33-60,87H2,(H,92,109)(H,93,110)(H,94,111)(H,95,112)(H,100,113)(H,101,114)(H,104,115)(H,105,116)(H3,90,102,117)(H3,91,103,118)(H4,88,96,98,106,119)(H4,89,97,99,107,120)/t69-,70-/m1/s1 |
PubChem CID | 91898590 |
ChEMBL | N/A |
IUPHAR | N/A |
BindingDB | 50442573 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 4000.0 nM | PMID24074877 | BindingDB |
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