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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Metabotropic glutamate receptor 6
Species	Rattus norvegicus (Rat)
Gene	Grm6
Synonym	nob3 nob2 nerg1 mGluR6 mGlu6 receptor Gprc1f glutamate receptor nob4 [ Show all ]
Disease	N/A for non-human GPCRs
Length	871
Amino acid sequence	MGRLPVLLLWLAWWLSQAGIACGAGSVRLAGGLTLGGLFPVHARGAAGRACGALKKEQGVHRLEAMLYALDRVNADPELLPGVRLGARLLDTCSRDTYALEQALSFVQALIRGRGDGDEASVRCPGGVPPLRSAPPERVVAVVGASASSVSIMVANVLRLFAIPQISYASTAPELSDSTRYDFFSRVVPPDSYQAQAMVDIVRALGWNYVSTLASEGNYGESGVEAFVQISREAGGVCIAQSIKIPREPKPGEFHKVIRRLMETPNARGIIIFANEDDIRRVLEATRQANLTGHFLWVGSDSWGSKISPILNLEEEAVGAITILPKRASIDGFDQYFMTRSLENNRRNIWFAEFWEENFNCKLTSSGGQSDDSTRKCTGEERIGQDSAYEQEGKVQFVIDAVYAIAHALHSMHQALCPGHTGLCPAMEPTDGRTLLHYIRAVRFNGSAGTPVMFNENGDAPGRYDIFQYQATNGSASSGGYQAVGQWAEALRLDMEVLRWSGDPHEVPPSQCSLPCGPGERKKMVKGVPCCWHCEACDGYRFQVDEFTCEACPGDMRPTPNHTGCRPTPVVRLTWSSPWAALPLLLAVLGIMATTTIMATFMRHNDTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPCAAICAARRLLLGLGTTLSYSALLTKTNRIYRIFEQGKRSVTPPPFISPTSQLVITFGLTSLQVVGVIAWLGAQPPHSVIDYEEQRTVDPEQARGVLKCDMSDLSLIGCLGYSLLLMVTCTVYAIKARGVPETFNEAKPIGFTMYTTCIIWLAFVPIFFGTAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKTYVILFHPEQNVQKRKRSLKKTSTMAAPPQNENAEDAK
UniProt	P35349
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3842
IUPHAR	294
DrugBank	N/A

Ligand

Name	L-PHOSPHINOTHRICIN
Molecular formula	C5H12NO4P
IUPAC name	(2S)-2-amino-4-[hydroxy(methyl)phosphoryl]butanoic acid
Molecular weight	181.128
Hydrogen bond acceptor	5
Hydrogen bond donor	3
XlogP	-5.0
Synonyms	(S)-Phosphinothricin@CRLF35597-44-5 C04650 35597-44-5 CHEMBL535153 SCHEMBL21986 (2S)-2-amino-4-[hydroxy(methyl)phosphoryl]butanoic acid AC1L3MFS L-Glufosinate ZINC902209 1fpy Phosphinothricine IAJOBQBIJHVGMQ-BYPYZUCNSA-N UNII-72P470U27C (S)-2-Amino-4-(hydroxy-methyl-phosphinoyl)-butyric acid; hydrochloride BDBM50174527 L-homoalanin-4-yl(methyl)phosphinic acid 2-AMINO-4-(HYDROXYMETHYL-PHOSPHINYL)BUTANOIC ACID CHEMBL145114 PPQ 72P470U27C L-2-Amino-4-(hydroxymethylphosphinyl)butanoate UNII-C8W4FP6BTY component IAJOBQBIJHVGMQ-BYPYZUCNSA-N [ Show all ]
Inchi Key	IAJOBQBIJHVGMQ-BYPYZUCNSA-N
Inchi ID	InChI=1S/C5H12NO4P/c1-11(9,10)3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)(H,9,10)/t4-/m0/s1
PubChem CID	91619
ChEMBL	CHEMBL145114
IUPHAR	N/A
BindingDB	50174527
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<500000.0 nM	PMID17722902	BindingDB,ChEMBL

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