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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Galanin receptor type 3
Species	Homo sapiens (Human)
Gene	GALR3
Synonym	GAL3-R Galnr3 GALR-3 GALR3 GAL3 receptor
Disease	Cognitive disorders
Length	368
Amino acid sequence	MADAQNISLDSPGSVGAVAVPVVFALIFLLGTVGNGLVLAVLLQPGPSAWQEPGSTTDLFILNLAVADLCFILCCVPFQATIYTLDAWLFGALVCKAVHLLIYLTMYASSFTLAAVSVDRYLAVRHPLRSRALRTPRNARAAVGLVWLLAALFSAPYLSYYGTVRYGALELCVPAWEDARRRALDVATFAAGYLLPVAVVSLAYGRTLRFLWAAVGPAGAAAAEARRRATGRAGRAMLAVAALYALCWGPHHALILCFWYGRFAFSPATYACRLASHCLAYANSCLNPLVYALASRHFRARFRRLWPCGRRRRHRARRALRRVRPASSGPPGCPGDARPSGRLLAGGGQGPEPREGPVHGGEAARGPE
UniProt	O60755
Protein Data Bank	N/A
GPCR-HGmod model	O60755
3D structure model	This predicted structure model is from GPCR-EXP O60755.
BioLiP	N/A
Therapeutic Target Database	T98494
ChEMBL	CHEMBL2731
IUPHAR	245
DrugBank	N/A

Ligand

Name	MLS001007488
Molecular formula	C16H17N3O2S
IUPAC name	N-[2-(3,4-dimethoxyphenyl)ethyl]thieno[2,3-d]pyrimidin-4-amine
Molecular weight	315.391
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	3.3
Synonyms	MCULE-8008936611 SR-01000051769-3 N-[2-(3,4-dimethoxyphenyl)ethyl]thieno[2,3-d]pyrimidin-4-amine HMS2714M18 SR-01000051769 AC1M1K0A SR-01000051769-4 CHEMBL1423660 SCHEMBL17456981 homoveratryl(thieno[2,3-d]pyrimidin-4-yl)amine SR-01000051769-1 BDBM97108 N-[2-(3,4-dimethoxyphenyl)ethyl]-4-thieno[2,3-d]pyrimidinamine cid_2100093 SMR000352663 [ Show all ]
Inchi Key	HZSOEMDGVPQNDT-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H17N3O2S/c1-20-13-4-3-11(9-14(13)21-2)5-7-17-15-12-6-8-22-16(12)19-10-18-15/h3-4,6,8-10H,5,7H2,1-2H3,(H,17,18,19)
PubChem CID	2100093
ChEMBL	CHEMBL1423660
IUPHAR	N/A
BindingDB	97108
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	371.44 nM	, PubChem BioAssay data set	BindingDB,ChEMBL

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