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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Histamine H4 receptor
Species	Homo sapiens (Human)
Gene	HRH4
Synonym	Pfi-013 SP9144 HH4R H4R H4 receptor GPRv53 GPCR105 G-protein coupled receptor 105 AXOR35 [ Show all ]
Disease	Allergic rhinitis Asthma Inflammatory disease Rheumatoid arthritis
Length	390
Amino acid sequence	MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
UniProt	Q9H3N8
Protein Data Bank	N/A
GPCR-HGmod model	Q9H3N8
3D structure model	This predicted structure model is from GPCR-EXP Q9H3N8.
BioLiP	N/A
Therapeutic Target Database	T26500
ChEMBL	CHEMBL3759
IUPHAR	265
DrugBank	BE0000146

Ligand

Name	BURIMAMIDE
Molecular formula	C9H16N4S
IUPAC name	1-[4-(1H-imidazol-5-yl)butyl]-3-methylthiourea
Molecular weight	212.315
Hydrogen bond acceptor	2
Hydrogen bond donor	3
XlogP	0.4
Synonyms	34970-69-9 DTXSID00188519 PDSP2_001081 LS-187654 TN5A4OD2TV 1-[4-(1H-imidazol-5-yl)butyl]-3-methylthiourea NCGC00167790-01 AC1MHUYH HXRBAVXGYZUSED-UHFFFAOYSA-N SCHEMBL7860369 C07448 N-(4-imidazol-4-ylbutyl)-N'-methylthiourea UNII-TN5A4OD2TV CHEMBL12160 PDSP1_001097 BDBM22888 LS-187038 Thiourea, N-(4-(1H-imidazol-4-yl)butyl)-N'-methyl- 1-[4-(1H-imidazol-5-yl)butyl]-3-methyl-thiourea CHEBI:3221 N-methyl-N'-[4-(4-imidazolyl)butyl]thiourea ZINC13831238 [ Show all ]
Inchi Key	HXRBAVXGYZUSED-UHFFFAOYSA-N
Inchi ID	InChI=1S/C9H16N4S/c1-10-9(14)12-5-3-2-4-8-6-11-7-13-8/h6-7H,2-5H2,1H3,(H,11,13)(H2,10,12,14)
PubChem CID	3032915
ChEMBL	CHEMBL12160
IUPHAR	N/A
BindingDB	22888
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	19.95 nM	PMID21044842	ChEMBL
Intrinsic activity	0.7 -	PMID21044842	ChEMBL
Ki	39.81 nM	PMID21044842	ChEMBL
Ki	40.0 nM	PMID15947036	BindingDB
Ki	180.0 nM	PMID12954048, PMID11179434	PDSP,BindingDB,ChEMBL

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