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Name | P2Y purinoceptor 2 |
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Species | Homo sapiens (Human) |
Gene | P2RY2 |
Synonym | Purinergic receptor purinergic receptor P2Y P2Y2 receptor P2Y2 P2Y purinoceptor 2 [ Show all ] |
Disease | Dry eye disease Constipation Cystic fibrosis Lung cancer |
Length | 377 |
Amino acid sequence | MAADLGPWNDTINGTWDGDELGYRCRFNEDFKYVLLPVSYGVVCVPGLCLNAVALYIFLCRLKTWNASTTYMFHLAVSDALYAASLPLLVYYYARGDHWPFSTVLCKLVRFLFYTNLYCSILFLTCISVHRCLGVLRPLRSLRWGRARYARRVAGAVWVLVLACQAPVLYFVTTSARGGRVTCHDTSAPELFSRFVAYSSVMLGLLFAVPFAVILVCYVLMARRLLKPAYGTSGGLPRAKRKSVRTIAVVLAVFALCFLPFHVTRTLYYSFRSLDLSCHTLNAINMAYKVTRPLASANSCLDPVLYFLAGQRLVRFARDAKPPTGPSPATPARRRLGLRRSDRTDMQRIEDVLGSSEDSRRTESTPAGSENTKDIRL |
UniProt | P41231 |
Protein Data Bank | N/A |
GPCR-HGmod model | P41231 |
3D structure model | This predicted structure model is from GPCR-EXP P41231. |
BioLiP | N/A |
Therapeutic Target Database | T93515 |
ChEMBL | CHEMBL4398 |
IUPHAR | 324 |
DrugBank | BE0002401 |
Name | CHEMBL413841 |
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Molecular formula | C10H17N2O15P3 |
IUPAC name | [[(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-methyl-2,4-dioxo-1H-pyrimidin-3-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate |
Molecular weight | 498.166 |
Hydrogen bond acceptor | 15 |
Hydrogen bond donor | 7 |
XlogP | -5.8 |
Synonyms | 6-methyl-3-beta-D-ribofuranosyl(1H)pyrimidine-2,4-dione 5''-triphosphate BDBM50199189 |
Inchi Key | AROARRWARGPJJC-ZOQUXTDFSA-N |
Inchi ID | InChI=1S/C10H17N2O15P3/c1-4-2-6(13)12(10(16)11-4)9-8(15)7(14)5(25-9)3-24-29(20,21)27-30(22,23)26-28(17,18)19/h2,5,7-9,14-15H,3H2,1H3,(H,11,16)(H,20,21)(H,22,23)(H2,17,18,19)/t5-,7-,8-,9-/m1/s1 |
PubChem CID | 11994009 |
ChEMBL | CHEMBL413841 |
IUPHAR | N/A |
BindingDB | 50199189 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Activity | 18.0 % | PMID17125260 | ChEMBL |
Activity | 93.0 % | PMID17125260 | ChEMBL |
EC50 | <1000.0 nM | PMID17125260 | BindingDB,ChEMBL |
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