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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Galanin receptor type 3
Species	Homo sapiens (Human)
Gene	GALR3
Synonym	GAL3-R Galnr3 GALR-3 GALR3 GAL3 receptor
Disease	Cognitive disorders
Length	368
Amino acid sequence	MADAQNISLDSPGSVGAVAVPVVFALIFLLGTVGNGLVLAVLLQPGPSAWQEPGSTTDLFILNLAVADLCFILCCVPFQATIYTLDAWLFGALVCKAVHLLIYLTMYASSFTLAAVSVDRYLAVRHPLRSRALRTPRNARAAVGLVWLLAALFSAPYLSYYGTVRYGALELCVPAWEDARRRALDVATFAAGYLLPVAVVSLAYGRTLRFLWAAVGPAGAAAAEARRRATGRAGRAMLAVAALYALCWGPHHALILCFWYGRFAFSPATYACRLASHCLAYANSCLNPLVYALASRHFRARFRRLWPCGRRRRHRARRALRRVRPASSGPPGCPGDARPSGRLLAGGGQGPEPREGPVHGGEAARGPE
UniProt	O60755
Protein Data Bank	N/A
GPCR-HGmod model	O60755
3D structure model	This predicted structure model is from GPCR-EXP O60755.
BioLiP	N/A
Therapeutic Target Database	T98494
ChEMBL	CHEMBL2731
IUPHAR	245
DrugBank	N/A

Ligand

Name	MLS003115736
Molecular formula	C11H13NOS
IUPAC name	4-methyl-4-(phenylsulfanylmethyl)azetidin-2-one
Molecular weight	207.291
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	1.7
Synonyms	NSC-299233 4-methyl-4-(phenylsulfanylmethyl)azetidin-2-one 4-methyl-4-[(phenylthio)methyl]azetidin-2-one DTXSID40316091 AC1L6ZBP NSC299233 CHEMBL2145430 4-methyl-4-phenylsulfanylmethyl-azetidin-2-one 53598-93-9 BDBM97181 SMR001831307 4-methyl-4-[(phenylthio)methyl]-2-azetidinone cid_326887 [ Show all ]
Inchi Key	HWNBODVECSTPNY-UHFFFAOYSA-N
Inchi ID	InChI=1S/C11H13NOS/c1-11(7-10(13)12-11)8-14-9-5-3-2-4-6-9/h2-6H,7-8H2,1H3,(H,12,13)
PubChem CID	326887
ChEMBL	CHEMBL2145430
IUPHAR	N/A
BindingDB	97181
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<29859.0 nM	, PubChem BioAssay data set	BindingDB,ChEMBL

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