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GPCR

NameEndothelin-1 receptor
SpeciesRattus norvegicus (Rat)
GeneEdnra
Synonymendothelin A receptor
Endothelin receptor type A {ECO:0000312|RGD:2535}
ENDOR
endothelin-1 receptor
ET-A
[ Show all ]
DiseaseN/A for non-human GPCRs
Length426
Amino acid sequenceMGVLCFLASFWLALVGGAIADNAERYSANLSSHVEDFTPFPGTEFNFLGTTLQPPNLALPSNGSMHGYCPQQTKITTAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLITAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEQHRTCMLNATTKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCHQSKSLMTSVPMNGTSIQWKNQEQNHNTERSSHKDSMN
UniProtP26684
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4566
IUPHAR219
DrugBankN/A

Ligand

NameCHEMBL65292
Molecular formulaC27H32O7
IUPAC name2-(1,3-benzodioxol-5-yl)-4-heptoxy-6-propan-2-yloxy-2H-chromene-3-carboxylic acid
Molecular weight468.546
Hydrogen bond acceptor7
Hydrogen bond donor1
XlogP6.3
SynonymsBDBM50112665
2-Benzo[1,3]dioxol-5-yl-4-heptyloxy-6-isopropoxy-2H-chromene-3-carboxylic acid
Inchi KeyAREOVFJGKBDFOX-UHFFFAOYSA-N
Inchi IDInChI=1S/C27H32O7/c1-4-5-6-7-8-13-30-26-20-15-19(33-17(2)3)10-12-21(20)34-25(24(26)27(28)29)18-9-11-22-23(14-18)32-16-31-22/h9-12,14-15,17,25H,4-8,13,16H2,1-3H3,(H,28,29)
PubChem CID10917653
ChEMBLCHEMBL65292
IUPHARN/A
BindingDB50112665
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC504.7 nMPMID11985472BindingDB,ChEMBL

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