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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Galanin receptor type 3
Species	Homo sapiens (Human)
Gene	GALR3
Synonym	GAL3-R Galnr3 GALR-3 GALR3 GAL3 receptor
Disease	Cognitive disorders
Length	368
Amino acid sequence	MADAQNISLDSPGSVGAVAVPVVFALIFLLGTVGNGLVLAVLLQPGPSAWQEPGSTTDLFILNLAVADLCFILCCVPFQATIYTLDAWLFGALVCKAVHLLIYLTMYASSFTLAAVSVDRYLAVRHPLRSRALRTPRNARAAVGLVWLLAALFSAPYLSYYGTVRYGALELCVPAWEDARRRALDVATFAAGYLLPVAVVSLAYGRTLRFLWAAVGPAGAAAAEARRRATGRAGRAMLAVAALYALCWGPHHALILCFWYGRFAFSPATYACRLASHCLAYANSCLNPLVYALASRHFRARFRRLWPCGRRRRHRARRALRRVRPASSGPPGCPGDARPSGRLLAGGGQGPEPREGPVHGGEAARGPE
UniProt	O60755
Protein Data Bank	N/A
GPCR-HGmod model	O60755
3D structure model	This predicted structure model is from GPCR-EXP O60755.
BioLiP	N/A
Therapeutic Target Database	T98494
ChEMBL	CHEMBL2731
IUPHAR	245
DrugBank	N/A

Ligand

Name	MLS002249163
Molecular formula	C15H16N4O5S2
IUPAC name	3-nitro-4-(4-thiophen-2-ylsulfonylpiperazin-1-yl)benzamide
Molecular weight	396.436
Hydrogen bond acceptor	8
Hydrogen bond donor	1
XlogP	1.4
Synonyms	3-nitro-4-[4-(2-thienylsulfonyl)piperazino]benzamide Z31101881 HMS3067C16 3-nitro-4-(4-thiophen-2-ylsulfonyl-1-piperazinyl)benzamide AKOS034151671 MolPort-004-278-449 3-nitro-4-[4-(thiophene-2-sulfonyl)piperazin-1-yl]benzamide CHEMBL1709973 ZINC9512178 AB00728405-01 MCULE-4432068332 3-nitro-4-(4-thiophen-2-ylsulfonylpiperazin-1-yl)benzamide BDBM97168 SMR001316611 790242-83-0 cid_3932658 AC1N061X [ Show all ]
Inchi Key	HTBGYCAMPKEQMQ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H16N4O5S2/c16-15(20)11-3-4-12(13(10-11)19(21)22)17-5-7-18(8-6-17)26(23,24)14-2-1-9-25-14/h1-4,9-10H,5-8H2,(H2,16,20)
PubChem CID	3932658
ChEMBL	CHEMBL1709973
IUPHAR	N/A
BindingDB	97168
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	1089.0 nM	, PubChem BioAssay data set	BindingDB,ChEMBL

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