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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	P2Y purinoceptor 2
Species	Homo sapiens (Human)
Gene	P2RY2
Synonym	Purinergic receptor purinergic receptor P2Y P2Y2 receptor P2Y2 P2Y purinoceptor 2 P2Y ATP receptor 2 P2U1 P2U receptor 1 P2U purinoceptor 1 ATP receptor [ Show all ]
Disease	Dry eye disease Constipation Cystic fibrosis Lung cancer
Length	377
Amino acid sequence	MAADLGPWNDTINGTWDGDELGYRCRFNEDFKYVLLPVSYGVVCVPGLCLNAVALYIFLCRLKTWNASTTYMFHLAVSDALYAASLPLLVYYYARGDHWPFSTVLCKLVRFLFYTNLYCSILFLTCISVHRCLGVLRPLRSLRWGRARYARRVAGAVWVLVLACQAPVLYFVTTSARGGRVTCHDTSAPELFSRFVAYSSVMLGLLFAVPFAVILVCYVLMARRLLKPAYGTSGGLPRAKRKSVRTIAVVLAVFALCFLPFHVTRTLYYSFRSLDLSCHTLNAINMAYKVTRPLASANSCLDPVLYFLAGQRLVRFARDAKPPTGPSPATPARRRLGLRRSDRTDMQRIEDVLGSSEDSRRTESTPAGSENTKDIRL
UniProt	P41231
Protein Data Bank	N/A
GPCR-HGmod model	P41231
3D structure model	This predicted structure model is from GPCR-EXP P41231.
BioLiP	N/A
Therapeutic Target Database	T93515
ChEMBL	CHEMBL4398
IUPHAR	324
DrugBank	BE0002401

Ligand

Name	UDP-glucose
Molecular formula	C15H24N2O17P2
IUPAC name	[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] hydrogen phosphate
Molecular weight	566.302
Hydrogen bond acceptor	17
Hydrogen bond donor	9
XlogP	-6.3
Synonyms	Uridine 5'-(trihydrogen diphosphate) alpha-D-gucopyranosyl ester Uridine 5'-diphosphoglucose Uridine diphosphoglucose ZINC8215472 AC1L1RDS co-waldenase GTPL1783 UNII-V50K1D7P4Y Uridine 5'-(trihydrogen diphosphate), P'-alpha-D-glucopyranosyl ester uridine 5'-[3-alpha-D-glucopyranosyl dihydrogen diphosphate] URIDINE-5'-DIPHOSPHATE-GLUCOSE C00029 D0DP9H Mono-D-glucosyl ester uridine 5''-[3-alpha-D-glucopyranosyl dihydrogen diphosphate] Uridine 5'-diphosphate glucose Uridine diphosphate-glucose URIDINE-5'-MONOPHOSPHATE GLUCOPYRANOSYL-MONOPHOSPHATE ESTER CHEMBL375951 EINECS 205-121-4 UDP-D-glucose UDPG Uridine 5'-(trihydrogen diphosphate), mono-alpha-d-glucopyranosyl ester Uridine 5'-pyrophosphate glucose ester Uridine pyrophosphate-glucose [[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] hydrogen phosphate BDBM50209659 Cogalactoisomerase GUD UPG Uridine 5'-(trihydrogen pyrophosphate), mono-alpha-D-glucopyranosyl ester (8CI) Uridine 5-(trihydrogen diphosphate) Uridine-5'-diphospho-glucose disodium salt 5''''-Diphosphoglucose CHEBI:46229 DB01861 SCHEMBL454078 Uridine 5'-(alpha-D-glucopyranosyl pyrophosphate) Uridine 5'-diphospho-alpha-D-glucose Uridine diphospho-D-glucose V50K1D7P4Y co-galactoisomerase GLUCOSE-URIDINE-C1,5'-DIPHOSPHATE UDP-Glc UDPglucose Uridine 5'-(trihydrogen diphosphate), P'-a-D-glucopyranosyl ester (9CI) Uridine 5'-pyrophosphate, alpha-D-glucopyranosyl ester (6CI,7CI) Uridine-5''''-Diphosphoglucose 133-89-1 BDBM50423218 D07MIE HSCJRCZFDFQWRP-JZMIEXBBSA-N Uridindiphosphoglucose Uridine 5'-(trihydrogen pyrophosphate), mono-D-glucosyl ester URIDINE DIPHOSPHATE GLUCOSE URIDINE-5'-DIPHOSPHOGLUCOSE 5'-Diphosphoglucose DTXSID00157902 UDP-alpha-D-Glucose [ Show all ]
Inchi Key	HSCJRCZFDFQWRP-JZMIEXBBSA-N
Inchi ID	InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/t5-,6-,8-,9-,10+,11-,12-,13-,14-/m1/s1
PubChem CID	8629
ChEMBL	CHEMBL375951
IUPHAR	1783
BindingDB	50209659, 50423218
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
EC50	10000.0 nM	PMID19502066	BindingDB,ChEMBL

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