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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	D(2) dopamine receptor
Species	Rattus norvegicus (Rat)
Gene	Drd2
Synonym	D2 receptor D2(415) and D₂₍₄₄₄₎ D2A and D_2B D2R Dopamine D2 receptor dopamine receptor 2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	444
Amino acid sequence	MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
UniProt	P61169
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL339
IUPHAR	215
DrugBank	N/A

Ligand

Name	o-Desmethyl metoclopramide
Molecular formula	C13H20ClN3O2
IUPAC name	4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-hydroxybenzamide
Molecular weight	285.772
Hydrogen bond acceptor	4
Hydrogen bond donor	3
XlogP	2.8
Synonyms	Metoclopramide specified impurity F [EP] 4-amino-5- chloro-N-[2-(diethylamino)ethyl]-2-hydroxybenzamide BDBM50023811 P5DX3Q3OG4 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-hydroxy benzamide ZINC4213841 2-Hydroxy-4-amino-5-chloro-N,N-diethylaminoethylbenzamide DTXSID40191704 N-[2-(Diethylamino)ethyl]-4-amino-5-chloro-2-hydroxybenzamide 4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-2-hydroxybenzamide Benzamide, 4-amino-5-chloro-N-(2-(diethylamino)ethyl)-2-hydroxy- SCHEMBL8746079 4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-2-hydroxybenz amide CHEMBL43695 38339-95-6 AKOS030577911 HPSMMIJTHMWCGC-UHFFFAOYSA-N 4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-hydroxy-benzamide Benzamide, 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-hydroxy- UNII-P5DX3Q3OG4 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-hydroxybenzamide CTK1B4964 [ Show all ]
Inchi Key	HPSMMIJTHMWCGC-UHFFFAOYSA-N
Inchi ID	InChI=1S/C13H20ClN3O2/c1-3-17(4-2)6-5-16-13(19)9-7-10(14)11(15)8-12(9)18/h7-8,18H,3-6,15H2,1-2H3,(H,16,19)
PubChem CID	9817332
ChEMBL	CHEMBL43695
IUPHAR	N/A
BindingDB	50023811
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
ED50	<40.0 mg.kg-1	PMID3397992	ChEMBL
IC50	<1000.0 nM	PMID3397992	BindingDB,ChEMBL

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