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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucagon-like peptide 1 receptor
Species	Homo sapiens (Human)
Gene	GLP1R
Synonym	glucagon-like peptide 1 receptor GLP-1R GLP-1-R GLP-1 receptor
Disease	Type 1/2 diabetes Type 1 diabetes Obesity Non-insulin dependent diabetes Non-alcoholic steatohepatitis Irritable bowel syndrome; Dyspepsia Unspecified Diabetes Brain injury Type 2 diabetes [ Show all ]
Length	463
Amino acid sequence	MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
UniProt	P43220
Protein Data Bank	5vex, 3c59, 3c5t, 5nx2, 3iol, 4zgm, 5otu, 5vew, 5otw, 5otx, 5otv
GPCR-HGmod model	P43220
3D structure model	This structure is from PDB ID 5vex.
BioLiP	BL0418498,BL0418499, BL0143794, BL0143795, BL0167479, BL0167480, BL0324354, BL0324355,BL0324356, BL0378791,BL0378792, BL0379513,BL0379514, BL0418500,BL0418501, BL0380967, BL0418494,BL0418495, BL0418496,BL0418497, BL0143732, BL0143731, BL0380966
Therapeutic Target Database	T36075
ChEMBL	CHEMBL1784
IUPHAR	249
DrugBank	BE0000857

Ligand

Name	N-(2-chlorobenzyl)-N'-(2-methylphenyl)-N-(pyridin-3-ylmethyl)thiourea
Molecular formula	C21H20ClN3S
IUPAC name	1-[(2-chlorophenyl)methyl]-3-(2-methylphenyl)-1-(pyridin-3-ylmethyl)thiourea
Molecular weight	381.922
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	4.6
Synonyms	ZINC3662249 HMS2720L22 MolPort-007-585-342 1-[(2-chlorophenyl)methyl]-3-(2-methylphenyl)-1-(pyridin-3-ylmethyl)thiourea SR-01000547719 MCULE-5051311391 AC1N4DO3 SR-01000547719-1 CHEMBL1509954 MLS000729620 SMR000307897 AKOS001775002 [ Show all ]
Inchi Key	HNYLELVFGLFRPB-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H20ClN3S/c1-16-7-2-5-11-20(16)24-21(26)25(14-17-8-6-12-23-13-17)15-18-9-3-4-10-19(18)22/h2-13H,14-15H2,1H3,(H,24,26)
PubChem CID	4153842
ChEMBL	CHEMBL1509954
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	8912.5 nM	PubChem BioAssay data set	ChEMBL

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