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GLASS

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GPCR

Name	Galanin receptor type 3
Species	Homo sapiens (Human)
Gene	GALR3
Synonym	GAL3-R Galnr3 GALR-3 GALR3 GAL3 receptor
Disease	Cognitive disorders
Length	368
Amino acid sequence	MADAQNISLDSPGSVGAVAVPVVFALIFLLGTVGNGLVLAVLLQPGPSAWQEPGSTTDLFILNLAVADLCFILCCVPFQATIYTLDAWLFGALVCKAVHLLIYLTMYASSFTLAAVSVDRYLAVRHPLRSRALRTPRNARAAVGLVWLLAALFSAPYLSYYGTVRYGALELCVPAWEDARRRALDVATFAAGYLLPVAVVSLAYGRTLRFLWAAVGPAGAAAAEARRRATGRAGRAMLAVAALYALCWGPHHALILCFWYGRFAFSPATYACRLASHCLAYANSCLNPLVYALASRHFRARFRRLWPCGRRRRHRARRALRRVRPASSGPPGCPGDARPSGRLLAGGGQGPEPREGPVHGGEAARGPE
UniProt	O60755
Protein Data Bank	N/A
GPCR-HGmod model	O60755
3D structure model	This predicted structure model is from GPCR-EXP O60755.
BioLiP	N/A
Therapeutic Target Database	T98494
ChEMBL	CHEMBL2731
IUPHAR	245
DrugBank	N/A

Ligand

Name	MLS000547376
Molecular formula	C13H12Cl3N3O2
IUPAC name	(2,4-dichlorophenyl)methyl N-(5-chloro-1,3-dimethylpyrazol-4-yl)carbamate
Molecular weight	348.608
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	3.9
Synonyms	(2,4-dichlorophenyl)methyl N-(5-chloro-1,3-dimethyl-1H-pyrazol-4-yl)carbamate BDBM90013 MolPort-002-860-787 SMR000180275 2,4-dichlorobenzyl N-(5-chloro-1,3-dimethyl-1H-pyrazol-4-yl)carbamate cid_3323365 ZINC4088928 AC1MOO0I MCULE-4751294409 (2,4-dichlorophenyl)methyl N-(5-chloro-1,3-dimethylpyrazol-4-yl)carbamate N-(5-chloro-1,3-dimethyl-4-pyrazolyl)carbamic acid (2,4-dichlorophenyl)methyl ester SR-01000689704 HMS2427B03 (2,4-dichlorophenyl)methyl N-(5-chloranyl-1,3-dimethyl-pyrazol-4-yl)carbamate AKOS005084104 1W-0276 CHEMBL1478769 N-(5-chloro-1,3-dimethyl-pyrazol-4-yl)carbamic acid (2,4-dichlorobenzyl) ester SR-01000689704-2 956755-44-5 KS-0000338B [ Show all ]
Inchi Key	HLYZKMCHUPJAEN-UHFFFAOYSA-N
Inchi ID	InChI=1S/C13H12Cl3N3O2/c1-7-11(12(16)19(2)18-7)17-13(20)21-6-8-3-4-9(14)5-10(8)15/h3-5H,6H2,1-2H3,(H,17,20)
PubChem CID	3323365
ChEMBL	CHEMBL1478769
IUPHAR	N/A
BindingDB	90013
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	2130.0 nM	, PubChem BioAssay data set	BindingDB,ChEMBL

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