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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Neuropeptide FF receptor 1
Species	Homo sapiens (Human)
Gene	NPFFR1
Synonym	GnIH-R G protein-coupled receptor 147 OT7T022 NPFF1R1 NPFF1 receptor NPFF1 G-protein coupled receptor 147 GPR147 GnIH-R/RFRP-3 RFamide-related peptide receptor OT7T022 [ Show all ]
Disease	N/A
Length	430
Amino acid sequence	MEGEPSQPPNSSWPLSQNGTNTEATPATNLTFSSYYQHTSPVAAMFIVAYALIFLLCMVGNTLVCFIVLKNRHMHTVTNMFILNLAVSDLLVGIFCMPTTLVDNLITGWPFDNATCKMSGLVQGMSVSASVFTLVAIAVERFRCIVHPFREKLTLRKALVTIAVIWALALLIMCPSAVTLTVTREEHHFMVDARNRSYPLYSCWEAWPEKGMRRVYTTVLFSHIYLAPLALIVVMYARIARKLCQAPGPAPGGEEAADPRASRRRARVVHMLVMVALFFTLSWLPLWALLLLIDYGQLSAPQLHLVTVYAFPFAHWLAFFNSSANPIIYGYFNENFRRGFQAAFRARLCPRPSGSHKEAYSERPGGLLHRRVFVVVRPSDSGLPSESGPSSGAPRPGRLPLRNGRVAHHGLPREGPGCSHLPLTIPAWDI
UniProt	Q9GZQ6
Protein Data Bank	N/A
GPCR-HGmod model	Q9GZQ6
3D structure model	This predicted structure model is from GPCR-EXP Q9GZQ6.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5951
IUPHAR	300
DrugBank	N/A

Ligand

Name	CHEMBL2208312
Molecular formula	C25H29N7O3
IUPAC name	N-[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]quinoline-2-carboxamide
Molecular weight	475.553
Hydrogen bond acceptor	5
Hydrogen bond donor	5
XlogP	1.3
Synonyms	BDBM50402447
Inchi Key	HLJNSDSPIPNDAP-FPOVZHCZSA-N
Inchi ID	InChI=1S/C25H29N7O3/c26-22(33)21(15-16-7-2-1-3-8-16)32-23(34)19(11-6-14-29-25(27)28)31-24(35)20-13-12-17-9-4-5-10-18(17)30-20/h1-5,7-10,12-13,19,21H,6,11,14-15H2,(H2,26,33)(H,31,35)(H,32,34)(H4,27,28,29)/t19-,21-/m0/s1
PubChem CID	71456103
ChEMBL	CHEMBL2208312
IUPHAR	N/A
BindingDB	50402447
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Inhibition	34.0 %	PMID23131340	ChEMBL
Inhibition	100.0 %	PMID23131340	ChEMBL
Ki	121.0 nM	PMID23131340	BindingDB,ChEMBL

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