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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	5-hydroxytryptamine receptor 5A
Species	Homo sapiens (Human)
Gene	HTR5A
Synonym	5-HT5alpha 5-HT-5 MR22 Htr5 5-HT-5A 5-HT5A 5HT5- 5-HT5A receptor 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled serotonin receptor 5A [ Show all ]
Disease	N/A
Length	357
Amino acid sequence	MDLPVNLTSFSLSTPSPLETNHSLGKDDLRPSSPLLSVFGVLILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEYTLRTRKCVSNVMIALTWALSAVISLAPLLFGWGETYSEGSEECQVSREPSYAVFSTVGAFYLPLCVVLFVYWKIYKAAKFRVGSRKTNSVSPISEAVEVKDSAKQPQMVFTVRHATVTFQPEGDTWREQKEQRAALMVGILIGVFVLCWIPFFLTELISPLCSCDIPAIWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAFKNFFSRQH
UniProt	P47898
Protein Data Bank	N/A
GPCR-HGmod model	P47898
3D structure model	This predicted structure model is from GPCR-EXP P47898.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3426
IUPHAR	10
DrugBank	BE0004688

Ligand

Name	MLS000735366
Molecular formula	C21H28N2O3S
IUPAC name	ethyl 1-[(2-methyl-1,3-thiazol-5-yl)methyl]-4-(2-phenoxyethyl)piperidine-4-carboxylate
Molecular weight	388.526
Hydrogen bond acceptor	6
Hydrogen bond donor	0
XlogP	3.8
Synonyms	MolPort-005-118-245 ethyl 1-[(2-methyl-1,3-thiazol-5-yl)methyl]-4-(2-phenoxyethyl)-4-piperidinecarboxylate SR-01000176827-1 MCULE-8385958346 SMR000319337 CHEMBL1345157 ethyl 1-[(2-methyl-1,3-thiazol-5-yl)methyl]-4-(2-phenoxyethyl)piperidine-4-carboxylate ZINC13595824 1-[(2-methyl-5-thiazolyl)methyl]-4-(2-phenoxyethyl)-4-piperidinecarboxylic acid ethyl ester BDBM83332 SR-01000176827 cid_16187535 HMS2675D15 1-[(2-methylthiazol-5-yl)methyl]-4-(2-phenoxyethyl)isonipecotic acid ethyl ester [ Show all ]
Inchi Key	AQDWISRSCBMKHV-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H28N2O3S/c1-3-25-20(24)21(11-14-26-18-7-5-4-6-8-18)9-12-23(13-10-21)16-19-15-22-17(2)27-19/h4-8,15H,3,9-14,16H2,1-2H3
PubChem CID	16187535
ChEMBL	CHEMBL1345157
IUPHAR	N/A
BindingDB	83332
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<92470.0 nM	PubChem BioAssay data set	ChEMBL

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