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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Alpha-2B adrenergic receptor
Species	Rattus norvegicus (Rat)
Gene	Adra2b
Synonym	ADRA2L1 alpha2B-adrenoceptor alpha2B alpha2-C2 alpha-2BAR alpha-2B adrenoreceptor Alpha-2B adrenoceptor Adra-2b adrenergic receptor Adrenergic alpha2B- receptor class III ADRA2RL1 alpha-2B adrenergic receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	453
Amino acid sequence	MSGPTMDHQEPYSVQATAAIASAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFWRAWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQRPEPRGLPQCELNQEAWYILASSIGSFFAPCLIMILVYLRIYVIAKRSHCRGLGAKRGSGEGESKKPQPVAGGVPTSAKVPTLVSPLSSVGEANGHPKPPREKEEGETPEDPEARALPPTWSALPRSGQGQKKGTSGATAEEGDEEDEEEVEECEPQTLPASPASVCNPPLQQPQTSRVLATLRGQVLLGKNVGVASGQWWRRRTQLSREKRFTFVLAVVIGVFVVCWFPFFFSYSLGAICPQHCKVPHGLFQFFFWIGYCNSSLNPVIYTVFNQDFRRAFRRILCRPWTQTGW
UniProt	P19328
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL266
IUPHAR	26
DrugBank	N/A

Ligand

Name	7-Hydroxychlorpromazine
Molecular formula	C17H19ClN2OS
IUPAC name	8-chloro-10-[3-(dimethylamino)propyl]phenothiazin-3-ol
Molecular weight	334.862
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	4.8
Synonyms	CCG-37119 MLS002920079 NSC 131053 PHENOTHIAZINE, 2-CHLORO-10-(3-(DIMETHYLAMINO)PROPYL)-7-HYDROXY- 7-Hydroxy Chlorpromazine 8-Chloro-10-[3-(dimethylamino)propyl]-10H-phenothiazin-3-ol CHEMBL909 NCGC00097415-01 NSC_16414 UNII-P0X9L6UVP0 BRN 1021503 hydroxychlorpromazine NCIStruc1_001431 Phenothiazin-3-ol, 8-chloro-10-(3-(dimethylamino)propyl)- (8CI) 10H-Phenothiazin-3-ol, 8-chloro-10-[3-(dimethylamino)propyl]- 7-OHCPZ CHEBI:125475 NCGC00014306 NSC-131053 SCHEMBL2389266 7-Hydroxy-2-chloro-10-(3'-(dimethylamino)-N-propyl)phenothiazine 8-Chloro-10-[3-(dimethylamino)propyl]-10H-phenothiazin-3-ol # DTXSID20175128 NCI131053 P0X9L6UVP0 WLN: T C666 BN ISJ B3N1&1 EG LQ 10H-Phenothiazin-3-ol, 8-chloro-10-(3-(dimethylamino)propyl)- 7-OCPZ AC1L27WF CAS_16414 LS-105368 NCIStruc2_001713 Phenothiazin-3-ol, 8-chloro-10-[3-(dimethylamino)propyl]- 2095-62-7 8-Chloro-10-(3-(dimethylamino)propyl)-10H-phenothiazin-3-ol NCGC00014306-02 NSC131053 SMR001797676 7-Hydroxy-2-chloro-10-[3'-(dimethylamino)-N-propyl]phenothiazine 8-chloro-10-[3-(dimethylamino)propyl]phenothiazin-3-ol BDBM81812 HICFFJZGXWEIHN-UHFFFAOYSA-N NCI60_000684 Phenothiazin-3-ol, 8-chloro-10-(3-(dimethylamino)propyl)- ZINC1717860 10H-Phenothiazin-3-ol, 8-chloro-10-(3-(dimethylamino)propyl)- (9CI) 7-OH-CHLORPROMAZINE [ Show all ]
Inchi Key	HICFFJZGXWEIHN-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H19ClN2OS/c1-19(2)8-3-9-20-14-6-5-13(21)11-17(14)22-16-7-4-12(18)10-15(16)20/h4-7,10-11,21H,3,8-9H2,1-2H3
PubChem CID	16414
ChEMBL	CHEMBL909
IUPHAR	N/A
BindingDB	81812
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	59.0 nM	PMID1656026	BindingDB

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