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GPCR

NameProstaglandin E2 receptor EP4 subtype
SpeciesMus musculus (Mouse)
GenePtger4
SynonymEP2
EP4 receptor
PGE receptor EP4 subtype
PGE2 receptor EP4 subtype
prostanoid EP4 receptor
DiseaseN/A for non-human GPCRs
Length513
Amino acid sequenceMAEVGGTIPRSNRELQRCVLLTTTIMSIPGVNASFSSTPERLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGDQALCDYSTFILLFFGLSGLSIICAMSIERYLAINHAYFYSHYVDKRLAGLTLFAIYASNVLFCALPNMGLGRSERQYPGTWCFIDWTTNVTAYAAFSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAAAVASVACRGHAGASPALQRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFINQLYQPNVVKDISRNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSGRDSSAQHCSESRRTSSAMSGHSRSFLARELKEISSTSQTLLYLPDLTESSLGGRNLLPGSHGMGLTQADTTSLRTLRISETSDSSQGQDSESVLLVDEVSGSHREEPASKGNSLQVTFPSETLKLSEKCI
UniProtP32240
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2489
IUPHAR343
DrugBankN/A

Ligand

Nameacrylic acid derivative, 16
Molecular formulaC28H24O4
IUPAC name(E)-3-[2-(2-naphthalen-2-ylethoxy)-4-(phenoxymethyl)phenyl]prop-2-enoic acid
Molecular weight424.496
Hydrogen bond acceptor4
Hydrogen bond donor1
XlogP6.5
SynonymsSCHEMBL2971211
CHEMBL593041
BDBM35859
SCHEMBL2971204
Inchi KeyHHJYFJGRTMWIMW-CCEZHUSRSA-N
Inchi IDInChI=1S/C28H24O4/c29-28(30)15-14-24-13-11-22(20-32-26-8-2-1-3-9-26)19-27(24)31-17-16-21-10-12-23-6-4-5-7-25(23)18-21/h1-15,18-19H,16-17,20H2,(H,29,30)/b15-14+
PubChem CID10273914
ChEMBLCHEMBL593041
IUPHARN/A
BindingDB35859
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Ki2600.0 nMPMID19700331BindingDB,ChEMBL

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