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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Lysophosphatidic acid receptor 3
Species	Homo sapiens (Human)
Gene	LPAR3
Synonym	Lysophosphatidic acid receptor Edg-7 LPA3 receptor LPA-3 LPA receptor 3 endothelial differentiation gene 7, lysophosphatidic acid G-protein-coupled receptor 7 Edg7 [ Show all ]
Disease	Fibrosis
Length	353
Amino acid sequence	MNECHYDKHMDFFYNRSNTDTVDDWTGTKLVIVLCVGTFFCLFIFFSNSLVIAAVIKNRKFHFPFYYLLANLAAADFFAGIAYVFLMFNTGPVSKTLTVNRWFLRQGLLDSSLTASLTNLLVIAVERHMSIMRMRVHSNLTKKRVTLLILLVWAIAIFMGAVPTLGWNCLCNISACSSLAPIYSRSYLVFWTVSNLMAFLIMVVVYLRIYVYVKRKTNVLSPHTSGSISRRRTPMKLMKTVMTVLGAFVVCWTPGLVVLLLDGLNCRQCGVQHVKRWFLLLALLNSVVNPIIYSYKDEDMYGTMKKMICCFSQENPERRPSRIPSTVLSRSDTGSQYIEDSISQGAVCNKSTS
UniProt	Q9UBY5
Protein Data Bank	N/A
GPCR-HGmod model	Q9UBY5
3D structure model	This predicted structure model is from GPCR-EXP Q9UBY5.
BioLiP	N/A
Therapeutic Target Database	T95923
ChEMBL	CHEMBL3250
IUPHAR	274
DrugBank	N/A

Ligand

Name	CHEMBL604677
Molecular formula	C21H12N2O7
IUPAC name	2-[3-(4-nitrophenoxy)phenyl]-1,3-dioxoisoindole-5-carboxylic acid
Molecular weight	404.334
Hydrogen bond acceptor	7
Hydrogen bond donor	1
XlogP	3.3
Synonyms	2-[3-(4-nitrophenoxy)phenyl]-1,3-dioxoisoindole-5-carboxylic acid H2L 5765834 AC1LRB4E SR-01000219364 2-(3-(4-nitrophenoxy)phenyl)-1,3-dioxoisoindoline-5-carboxylic acid ZINC1210352 420841-84-5 MolPort-002-166-934 AKOS024458388 SR-01000219364-1 2-[3-(4-nitrophenoxy)phenyl]-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylic acid Oprea1_676785 2,3-Dihydro-2-[3-(4-nitrophenoxy)phenyl]-1,3-dioxo-1H-isoindole-5-carboxylic acid BDBM50304580 STL508167 [ Show all ]
Inchi Key	HFYPTENHTPNXGP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H12N2O7/c24-19-17-9-4-12(21(26)27)10-18(17)20(25)22(19)14-2-1-3-16(11-14)30-15-7-5-13(6-8-15)23(28)29/h1-11H,(H,26,27)
PubChem CID	1365686
ChEMBL	CHEMBL604677
IUPHAR	N/A
BindingDB	50304580
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	752.0 nM	PMID19800804	BindingDB,ChEMBL
Ki	230.0 nM	PMID19800804	BindingDB,ChEMBL

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