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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucagon-like peptide 1 receptor
Species	Homo sapiens (Human)
Gene	GLP1R
Synonym	glucagon-like peptide 1 receptor GLP-1R GLP-1-R GLP-1 receptor
Disease	Type 1/2 diabetes Type 1 diabetes Obesity Non-insulin dependent diabetes Non-alcoholic steatohepatitis Irritable bowel syndrome; Dyspepsia Unspecified Diabetes Brain injury Type 2 diabetes [ Show all ]
Length	463
Amino acid sequence	MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
UniProt	P43220
Protein Data Bank	5vex, 3c59, 3c5t, 5nx2, 3iol, 4zgm, 5otu, 5vew, 5otw, 5otx, 5otv
GPCR-HGmod model	P43220
3D structure model	This structure is from PDB ID 5vex.
BioLiP	BL0418498,BL0418499, BL0143794, BL0143795, BL0167479, BL0167480, BL0324354, BL0324355,BL0324356, BL0378791,BL0378792, BL0379513,BL0379514, BL0418500,BL0418501, BL0380967, BL0418494,BL0418495, BL0418496,BL0418497, BL0143732, BL0143731, BL0380966
Therapeutic Target Database	T36075
ChEMBL	CHEMBL1784
IUPHAR	249
DrugBank	BE0000857

Ligand

Name	MLS002166510
Molecular formula	C24H26O7
IUPAC name	(2-oxooxolan-3-yl) 2-(3,4-dipropoxybenzoyl)benzoate
Molecular weight	426.465
Hydrogen bond acceptor	7
Hydrogen bond donor	0
XlogP	4.9
Synonyms	2-(3,4-dipropoxybenzoyl)benzoic acid (2-ketotetrahydrofuran-3-yl) ester CHEMBL1483683 AC1NNCSR MCULE-3382072684 (2-oxidanylideneoxolan-3-yl) 2-(3,4-dipropoxyphenyl)carbonylbenzoate BDBM79595 SMR001248858 2-[(3,4-dipropoxyphenyl)-oxomethyl]benzoic acid (2-oxo-3-oxolanyl) ester cid_5024835 AKOS001043856 (2-oxooxolan-3-yl) 2-(3,4-dipropoxybenzoyl)benzoate HMS3065K17 AKOS016858859 MolPort-003-249-986 [ Show all ]
Inchi Key	APUOHHVGNOQUIR-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H26O7/c1-3-12-28-19-10-9-16(15-21(19)29-13-4-2)22(25)17-7-5-6-8-18(17)23(26)31-20-11-14-30-24(20)27/h5-10,15,20H,3-4,11-14H2,1-2H3
PubChem CID	5024835
ChEMBL	CHEMBL1483683
IUPHAR	N/A
BindingDB	79595
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	12589.3 nM	PubChem BioAssay data set	ChEMBL

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