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GPCR

NameGrowth hormone secretagogue receptor type 1
SpeciesRattus norvegicus (Rat)
GeneGhsr
SynonymGH-releasing peptide receptor
Ghrelin receptor
ghrelin receptor 1a
GHRP
GHS-R
[ Show all ]
DiseaseN/A for non-human GPCRs
Length364
Amino acid sequenceMWNATPSEEPEPNVTLDLDWDASPGNDSLPDELLPLFPAPLLAGVTATCVALFVVGISGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVILVIWAVAFCSAGPIFVLVGVEHENGTDPRDTNECRATEFAVRSGLLTVMVWVSSVFFFLPVFCLTVLYSLIGRKLWRRRGDAAVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFKLLGFESFSQRKLSTLKDESSRAWTKSSINT
UniProtO08725
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3278
IUPHAR246
DrugBankN/A

Ligand

NameCHEMBL268518
Molecular formulaC28H34N4O2
IUPAC name2-amino-N-[(2R)-3-(1H-indol-3-yl)-1-oxo-1-spiro[1,3-dihydroindene-2,4'-piperidine]-1'-ylpropan-2-yl]-2-methylpropanamide
Molecular weight458.606
Hydrogen bond acceptor3
Hydrogen bond donor3
XlogP3.3
Synonyms1N-[1-(1H-3-indolylmethyl)-2-oxo-2-spiro[2,3-dihydro-1H-indene-2,4''-(hexahydropyridine)]-1-yl-(1R)-ethyl]-2-amino-2-methylpropanamide
BDBM50073030
Inchi KeyHDLPVLYONYYNIJ-XMMPIXPASA-N
Inchi IDInChI=1S/C28H34N4O2/c1-27(2,29)26(34)31-24(15-21-18-30-23-10-6-5-9-22(21)23)25(33)32-13-11-28(12-14-32)16-19-7-3-4-8-20(19)17-28/h3-10,18,24,30H,11-17,29H2,1-2H3,(H,31,34)/t24-/m1/s1
PubChem CID22867465
ChEMBLCHEMBL268518
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC5037.0 nMPMID9925440ChEMBL

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