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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	P2Y purinoceptor 2
Species	Homo sapiens (Human)
Gene	P2RY2
Synonym	Purinergic receptor purinergic receptor P2Y P2Y2 receptor P2Y2 P2Y purinoceptor 2 P2Y ATP receptor 2 P2U1 P2U receptor 1 P2U purinoceptor 1 ATP receptor [ Show all ]
Disease	Dry eye disease Constipation Cystic fibrosis Lung cancer
Length	377
Amino acid sequence	MAADLGPWNDTINGTWDGDELGYRCRFNEDFKYVLLPVSYGVVCVPGLCLNAVALYIFLCRLKTWNASTTYMFHLAVSDALYAASLPLLVYYYARGDHWPFSTVLCKLVRFLFYTNLYCSILFLTCISVHRCLGVLRPLRSLRWGRARYARRVAGAVWVLVLACQAPVLYFVTTSARGGRVTCHDTSAPELFSRFVAYSSVMLGLLFAVPFAVILVCYVLMARRLLKPAYGTSGGLPRAKRKSVRTIAVVLAVFALCFLPFHVTRTLYYSFRSLDLSCHTLNAINMAYKVTRPLASANSCLDPVLYFLAGQRLVRFARDAKPPTGPSPATPARRRLGLRRSDRTDMQRIEDVLGSSEDSRRTESTPAGSENTKDIRL
UniProt	P41231
Protein Data Bank	N/A
GPCR-HGmod model	P41231
3D structure model	This predicted structure model is from GPCR-EXP P41231.
BioLiP	N/A
Therapeutic Target Database	T93515
ChEMBL	CHEMBL4398
IUPHAR	324
DrugBank	BE0002401

Ligand

Name	CHEMBL1767418
Molecular formula	C11H17N2O8PS
IUPAC name	[(2R,3S,4R,5R)-5-(2-ethylsulfanyl-4-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate
Molecular weight	368.297
Hydrogen bond acceptor	9
Hydrogen bond donor	4
XlogP	-1.5
Synonyms	2-Ethylthio-1-beta-D-ribofuranosylpyrimidine-4-one-5''-monophosphate BDBM50341889
Inchi Key	HAIWBDSVRZGGKI-PEBGCTIMSA-N
Inchi ID	InChI=1S/C11H17N2O8PS/c1-2-23-11-12-7(14)3-4-13(11)10-9(16)8(15)6(21-10)5-20-22(17,18)19/h3-4,6,8-10,15-16H,2,5H2,1H3,(H2,17,18,19)/t6-,8-,9-,10-/m1/s1
PubChem CID	52952395
ChEMBL	CHEMBL1767418
IUPHAR	N/A
BindingDB	50341889
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	1500.0 nM	PMID21417463	BindingDB,ChEMBL

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