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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Melanin-concentrating hormone receptor 1
Species	Homo sapiens (Human)
Gene	MCHR1
Synonym	SLC-1 Somatostatin receptor-like protein MCHR-1 MCHR MCH1R MCH1 receptor MCH-R1 MCH-1R MCH receptor 1 GPR24 G-protein coupled receptor 24 G protein-coupled receptor 24 [ Show all ]
Disease	Obesity Obesity; Anxiety; Depression
Length	422
Amino acid sequence	MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
UniProt	Q99705
Protein Data Bank	N/A
GPCR-HGmod model	Q99705
3D structure model	This predicted structure model is from GPCR-EXP Q99705.
BioLiP	N/A
Therapeutic Target Database	T09572
ChEMBL	CHEMBL344
IUPHAR	280
DrugBank	BE0003478

Ligand

Name	T-226296
Molecular formula	C26H27FN2O
IUPAC name	N-[6-[(dimethylamino)methyl]-5,6,7,8-tetrahydronaphthalen-2-yl]-4-(4-fluorophenyl)benzamide
Molecular weight	402.513
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	5.4
Synonyms	4''-Fluoro-biphenyl-4-carboxylic acid (6-dimethylaminomethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-amide D0TV4N N-[6-(dimethylaminomethyl)-5,6,7,8-tetrahydronaphthalen-2-yl]-4-(4-fluorophenyl)benzamide KB-80782 S-20951 102690-EP2272841A1 331758-35-1 CHEMBL178707 N-(6-((dimethylamino)methyl)-5,6,7,8-tetrahydronaphthalen-2-yl)-4''-fluorobiphenyl-4-carboxamide 4'-Fluoro-N-[6-[(N,N-dimethylamino)methyl]-5,6,7,8-tetrahydro-2-naphthalenyl)[1,1'-biphenyl]-4-carboxamide GTPL1314 PDSP1_000981 BDBM50150715 LS-193063 SCHEMBL5582818 102690-EP2301936A1 4''''-Fluoro-biphenyl-4-carboxylic acid (6-dimethylaminomethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-amide D0L1IZ N-(6-((dimethylamino)methyl)-5,6,7,8-tetrahydronaphthalen-2-yl)-4'-fluoro-[1,1'-biphenyl]-4-carboxamide T226296 4'-Fluoro-N-[6-[(N,N-dimethylamino)methyl]-5,6,7,8-tetrahydro-2-naphthalenyl][1,1'-biphenyl]-4-carboxamide GXAQELJVODWLDD-UHFFFAOYSA-N PDSP2_000965 LS-44229 T 226296 [ Show all ]
Inchi Key	GXAQELJVODWLDD-UHFFFAOYSA-N
Inchi ID	InChI=1S/C26H27FN2O/c1-29(2)17-18-3-4-23-16-25(14-11-22(23)15-18)28-26(30)21-7-5-19(6-8-21)20-9-12-24(27)13-10-20/h5-14,16,18H,3-4,15,17H2,1-2H3,(H,28,30)
PubChem CID	9865843
ChEMBL	CHEMBL178707
IUPHAR	1314
BindingDB	50150715
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	5.01 nM	PMID11909603	IUPHAR
IC50	5.5 nM	PMID15267235, PMID21190859, PMID19773162, PMID21975069	BindingDB,ChEMBL
IC50	14.0 nM	PMID21856163	BindingDB,ChEMBL
IC50	19.0 nM	PMID19290642	BindingDB,ChEMBL
IC50	43.0 nM	PMID21856163	BindingDB,ChEMBL
IC50	85.0 nM	PMID15341943	BindingDB,ChEMBL
IC50	872.0 nM	PMID15341943	ChEMBL
Ki	5.5 nM	PMID15686900	BindingDB,ChEMBL
Ki	38.0 nM	PMID17448659	BindingDB,ChEMBL

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