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GLASS

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GPCR

Name	5-hydroxytryptamine receptor 7
Species	Homo sapiens (Human)
Gene	HTR7
Synonym	5-HT-7 Serotonin receptor 7 5-HT-X 5-HT1Y 5-HT7 GPRFO 5-HT7 receptor 5-HTx 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled [ Show all ]
Disease	Sleep disorders Schizophrenia Major depressive disorder
Length	479
Amino acid sequence	MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD
UniProt	P34969
Protein Data Bank	N/A
GPCR-HGmod model	P34969
3D structure model	This predicted structure model is from GPCR-EXP P34969.
BioLiP	N/A
Therapeutic Target Database	T79062
ChEMBL	CHEMBL3155
IUPHAR	12
DrugBank	BE0000650, BE0004862

Ligand

Name	CHEMBL319005
Molecular formula	C19H20N2O
IUPAC name	1-[(3-methoxyphenyl)methyl]-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole
Molecular weight	292.382
Hydrogen bond acceptor	2
Hydrogen bond donor	2
XlogP	3.4
Synonyms	1-[(3-methoxyphenyl)methyl]-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole NSC 165209 AC1L9OAN 1-(3-Methoxybenzyl)-2,3,4,9-tetrahydro-1H-beta-carboline NSC165209 1-(3-Methoxy-benzyl)-2,3,4,9-tetrahydro-1H-beta-carboline BDBM50206163 1-(3-methoxybenzyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole Methyl 3-(2,3,4,9-tetrahydro-1H-.beta.-carbolin-1-ylmethyl)phenyl ether 54313-39-2 1-(3-Methoxybenzyl)-2,3,4,9-tetrahydro-1H-.beta.-carboline [ Show all ]
Inchi Key	GVVVUTQKKBTPEY-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H20N2O/c1-22-14-6-4-5-13(11-14)12-18-19-16(9-10-20-18)15-7-2-3-8-17(15)21-19/h2-8,11,18,20-21H,9-10,12H2,1H3
PubChem CID	424430
ChEMBL	CHEMBL319005
IUPHAR	N/A
BindingDB	50206163
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	26.0 nM	PMID17317171	BindingDB,ChEMBL

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