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GLASS

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GPCR

Name	Galanin receptor type 3
Species	Homo sapiens (Human)
Gene	GALR3
Synonym	GAL3-R Galnr3 GALR-3 GALR3 GAL3 receptor
Disease	Cognitive disorders
Length	368
Amino acid sequence	MADAQNISLDSPGSVGAVAVPVVFALIFLLGTVGNGLVLAVLLQPGPSAWQEPGSTTDLFILNLAVADLCFILCCVPFQATIYTLDAWLFGALVCKAVHLLIYLTMYASSFTLAAVSVDRYLAVRHPLRSRALRTPRNARAAVGLVWLLAALFSAPYLSYYGTVRYGALELCVPAWEDARRRALDVATFAAGYLLPVAVVSLAYGRTLRFLWAAVGPAGAAAAEARRRATGRAGRAMLAVAALYALCWGPHHALILCFWYGRFAFSPATYACRLASHCLAYANSCLNPLVYALASRHFRARFRRLWPCGRRRRHRARRALRRVRPASSGPPGCPGDARPSGRLLAGGGQGPEPREGPVHGGEAARGPE
UniProt	O60755
Protein Data Bank	N/A
GPCR-HGmod model	O60755
3D structure model	This predicted structure model is from GPCR-EXP O60755.
BioLiP	N/A
Therapeutic Target Database	T98494
ChEMBL	CHEMBL2731
IUPHAR	245
DrugBank	N/A

Ligand

Name	MLS001180182
Molecular formula	C14H14N4S2
IUPAC name	4-(2,4-dimethyl-1,3-thiazol-5-yl)-N-(4-methylpyridin-2-yl)-1,3-thiazol-2-amine
Molecular weight	302.414
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	4.0
Synonyms	2',4'-dimethyl-{N}-(4-methylpyridin-2-yl)-4,5'-bi-1,3-thiazol-2-amine BDBM97133 SMR000476285 4-(2,4-dimethyl-5-thiazolyl)-N-(4-methyl-2-pyridinyl)-2-thiazolamine;hydrobromide cid_2877321 ZINC4116988 AC1MEEXP MolPort-000-690-688 4-(2,4-dimethyl-1,3-thiazol-5-yl)-N-(4-methylpyridin-2-yl)-1,3-thiazol-2-amine CCG-120129 SR-01000477299 MCULE-3732896271 [4-(2,4-dimethylthiazol-5-yl)thiazol-2-yl]-(4-methyl-2-pyridyl)amine;hydrobromide AKOS001700994 N-(4-methyl-2-pyridinyl)-N-[2',4'-dimethyl-4,5'-bis(1,3-thiazole)-2-yl]amine 4-(2,4-dimethyl-1,3-thiazol-5-yl)-N-(4-methylpyridin-2-yl)-1,3-thiazol-2-amine;hydrobromide CHEMBL1740522 SR-01000477299-1 AB00101255-01 [ Show all ]
Inchi Key	GSIAWGVMMLXTJT-UHFFFAOYSA-N
Inchi ID	InChI=1S/C14H14N4S2/c1-8-4-5-15-12(6-8)18-14-17-11(7-19-14)13-9(2)16-10(3)20-13/h4-7H,1-3H3,(H,15,17,18)
PubChem CID	2877322
ChEMBL	N/A
IUPHAR	N/A
BindingDB	97133
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<29961.0 nM	N/A	BindingDB

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