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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 6
Species	Homo sapiens (Human)
Gene	HTR6
Synonym	5-HT6 receptor 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 5-HT-6 serotonin receptor 6 ST-B17 5-HT6 [ Show all ]
Disease	Schizophrenia Obesity Neurological disease Neurodegenerative disease Emesis Cognitive disorders Unspecified Anxiety disorder Alzheimer disease; Dementia Alzheimer disease; Anxiety disorder Alzheimer disease [ Show all ]
Length	440
Amino acid sequence	MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN
UniProt	P50406
Protein Data Bank	N/A
GPCR-HGmod model	P50406
3D structure model	This predicted structure model is from GPCR-EXP P50406.
BioLiP	N/A
Therapeutic Target Database	T16691
ChEMBL	CHEMBL3371
IUPHAR	11
DrugBank	BE0000945

Ligand

Name	CHEMBL1642876
Molecular formula	C23H22N4O3S
IUPAC name	N-(3-naphthalen-1-ylsulfonyl-2H-indazol-7-yl)piperidine-4-carboxamide
Molecular weight	434.514
Hydrogen bond acceptor	5
Hydrogen bond donor	3
XlogP	3.1
Synonyms	CHEMBL1739544 BDBM50334744 N-(3-(Naphthalen-1-ylsulfonyl)-1H-indazol-7-yl)piperidine-4-carboxamide HCl SCHEMBL3553846
Inchi Key	AOAFAFLOTNULTE-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H22N4O3S/c28-22(16-11-13-24-14-12-16)25-19-9-4-8-18-21(19)26-27-23(18)31(29,30)20-10-3-6-15-5-1-2-7-17(15)20/h1-10,16,24H,11-14H2,(H,25,28)(H,26,27)
PubChem CID	16116897
ChEMBL	N/A
IUPHAR	N/A
BindingDB	50334744
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	28.0 nM	PMID21093272	BindingDB

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