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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Prostaglandin F2-alpha receptor
Species	Bos taurus (Bovine)
Gene	PTGFR
Synonym	PGF receptor PGF2-alpha receptor Prostanoid FP receptor
Disease	N/A for non-human GPCRs
Length	362
Amino acid sequence	MSTNSSIQPVSPESELLSNTTCQLEEDLSISFSIIFMTVGILSNSLAIAILMKAYQRFRQKYKSSFLLLASALVITDFFGHLINGTIAVFVYASDKDWIYFDKSNILCSIFGICMVFSGLCPLFLGSLMAIERCIGVTKPIFHSTKITTKHVKMMLSGVCFFAVFVALLPILGHRDYKIQASRTWCFYKTDEIKDWEDRFYLLLFAFLGLLALGISFVCNAITGISLLKVKFRSQQHRQGRSHHFEMVIQLLGIMCVSCICWSPFLVTMASIGMNIQDFKDSCERTLFTLRMATWNQILDPWVYILLRKAVLRNLYVCTRRCCGVHVISLHVWELSSIKDSLKVAAISDLPVTEKVTQQTST
UniProt	P37289
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4820
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	8-iso Prostaglandin E1
Molecular formula	C20H34O5
IUPAC name	7-[3-hydroxy-2-(3-hydroxyoct-1-enyl)-5-oxocyclopentyl]heptanoic acid
Molecular weight	354.487
Hydrogen bond acceptor	5
Hydrogen bond donor	3
XlogP	3.2
Synonyms	AC1L18QG SCHEMBL5303767 21003-46-3 CTK8F7408 7-[3-hydroxy-2-(3-hydroxyoct-1-enyl)-5-oxocyclopentyl]heptanoic acid MCULE-5248179465 119314-69-1 ACMC-20moau 7-[3-hydroxy-2-(3-hydroxyoct-1-enyl)-5-keto-cyclopentyl]enanthic acid HMS3394L11 Prost-13-en-1-oic acid,11,15-dihydroxy-9-oxo-, (11a,13E,15S)-, homopolymer (9CI) 11alpha,13E,15S]-11,15-Dihydroxy-9-oxoprosta-13-en-1-oic acid AN-10384 7-[3-hydroxy-2-(3-hydroxyoct-1-enyl)-5-oxo-cyclopentyl]heptanoic acid HMS3654H18 [ Show all ]
Inchi Key	GMVPRGQOIOIIMI-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)
PubChem CID	214
ChEMBL	N/A
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<10000.0 nM	PMID9694973	PDSP

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