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I-TASSER I-TASSER-MTD C-I-TASSER CR-I-TASSER QUARK C-QUARK LOMETS MUSTER CEthreader SEGMER DeepFold DeepFoldRNA FoldDesign COFACTOR COACH MetaGO TripletGO IonCom FG-MD ModRefiner REMO DEMO DEMO-EM DMFold SPRING COTH Threpp PEPPI BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign BindProf BindProfX SSIPe GPCR-I-TASSER MAGELLAN ResQ STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes DeepPotential WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner GPU-I-TASSER

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

BioLiP
>protein
TKGTSSFGKRRNKTHTLCRRCGSKAYHLQKSTCGKCGYPAKRKRKYNWSAKAKRRNTTGTGRMRHLKIVYRRFRHGFREG
TTPKPK

The query sequence (length=86) is searched through a non-redundant set of database sequences protein_nr.fasta.gz clustered at 90% identity cutoff to identify representative hits. Homologs that belong to the same sequence cluster of the representative hit are listed in the last column of the table.

# Hit Hit
length
Aligned
length
Identity
(normalized by query)
Identity
(normalized by hit)
Identity (normalized
by aligned length)
E-value Homologs
to hit
1 4v6x:Cj 90 86 1.0000 0.9556 1.0000 8.94e-58 7a01:C2, 8a3d:d, 5aj0:Aj, 8b5l:j, 8b6c:j, 9bdl:AL37, 9bdn:AL37, 9bdp:AL37, 7bhp:Lj, 8bhf:W1, 8bpo:i2, 8btk:Bj, 7cpu:Lj, 7cpv:Lj, 4d5y:j, 4d67:j, 6d90:j, 6d9j:j, 9f1b:Bj, 9f1c:Bj, 9f1d:Bj, 7f5s:Lj, 8fkp:LW, 8fkq:LW, 8fkr:LW, 8fks:LW, 8fkt:LW, 8fku:LW, 8fkv:LW, 8fkw:LW, 8fkx:LW, 8fky:LW, 8fkz:LW, 8fl2:LW, 8fl3:LW, 8fl4:LW, 8fl6:LW, 8fl7:LW, 8fl9:LW, 8fla:LW, 8flb:LW, 8flc:LW, 8fld:LW, 8fle:LW, 8flf:LW, 6frk:j, 6ftg:j, 6fti:j, 6ftj:j, 8g5y:Lj, 8g5z:Lj, 8g60:Lj, 8g61:Lj, 8g6j:Lj, 8glp:Lj, 6gz3:Aj, 6gz4:Aj, 6gz5:Aj, 6hcf:j3, 6hcj:j3, 6hcm:j3, 6hcq:j3, 8idt:M, 8idy:M, 8ie3:M, 8ifd:2d, 8ife:2d, 8ine:M, 8inf:M, 8ink:M, 6ip5:2d, 6ip6:2d, 6ip8:2d, 8ipd:M, 8ipx:M, 8ipy:M, 8ir1:M, 8ir3:M, 3j7o:j, 3j7p:j, 3j7q:j, 3j7r:j, 3j92:j, 3jag:j, 3jah:j, 3jai:j, 3jaj:j, 3jan:j, 8jdj:o, 8jdk:o, 8jdl:o, 8jdm:o, 8k2c:Lj, 5lks:Lj, 6lqm:M, 6lsr:M, 6lss:M, 7ls1:d2, 7ls2:d2, 6lu8:M, 5lzs:j, 5lzt:j, 5lzu:j, 5lzv:j, 5lzw:j, 5lzx:j, 5lzy:j, 5lzz:j, 7mdz:j, 6mtb:j, 6mtc:j, 6mtd:j, 6mte:j, 7nfx:j, 7nwg:j3, 7nwh:j, 7nwi:j, 7o7y:Bj, 7o7z:Bj, 7o80:Bj, 7o81:Bj, 7obr:j, 8ohd:Lj, 8oj0:Lj, 8oj5:Lj, 8oj8:Lj, 6ole:k, 6olf:k, 6olg:Aj, 6oli:k, 6olz:Aj, 6om0:k, 6om7:k, 7ow7:d, 7oya:j1, 7oyb:j1, 7oyc:j1, 7oyd:j, 8p2k:Bj, 6p5i:Aj, 6p5j:Aj, 6p5k:Aj, 6p5n:Aj, 8q7z:Bj, 8q87:Bj, 8qfd:j, 7qgg:k, 8qoi:Lj, 7qvp:Mj, 7qvp:Lj, 7qwq:j, 7qwr:j, 7qws:j, 6qzp:Lj, 6r5q:j, 6r6g:j, 6r6p:j, 6r7q:j, 8rjb:j, 8rjc:j, 8rjd:j, 8scb:j, 6sgc:j2, 6swa:h, 5t2c:d, 6t59:j3, 7tm3:j, 7toq:AL37, 7tor:AL37, 7tut:j, 7ucj:j, 7uck:j, 4ug0:Lj, 4ujc:Bj, 4ujd:Aj, 4uje:Cj, 4v5z:B2, 6w6l:k, 6xa1:Lj, 7xnx:Lj, 7xny:Lj, 8xsx:Lj, 8xsy:Lj, 8xsz:Lj, 6y0g:Lj, 8y0w:Lj, 8y0x:Lj, 6y2l:Lj, 6y57:Lj, 6y6x:Lj, 8yoo:Lj, 8yop:Lj, 6z6l:Lj, 6z6m:Lj, 6z6n:Lj, 7zjw:Lm, 7zjx:Lm, 6zm7:Lj, 6zme:Lj, 6zmi:Lj, 6zmo:Lj, 6zvk:C2
2 4v6w:Cj 92 86 0.7791 0.7283 0.7791 4.82e-45 6xu8:Cj
3 8bf9:j 73 86 0.8372 0.9863 0.8372 3.88e-42
4 4v3p:Ll 94 85 0.6977 0.6383 0.7059 2.95e-38 8ip8:UA, 8ipa:UA, 8ipb:UA, 8jiv:Cj, 4v7e:Cj
5 7qiw:l 87 85 0.6744 0.6667 0.6824 3.24e-36 8azw:V, 8b2l:V3, 7qiz:l
6 6xu6:Cj 87 86 0.6628 0.6552 0.6628 1.59e-35 6xu7:Cj
7 4v6i:Bl 88 84 0.6395 0.6250 0.6548 2.71e-35 8aaf:W, 8agt:W, 8agu:W, 8agv:W, 8agw:W, 8agx:W, 8agz:W, 5apn:j, 5apo:j, 7azy:g, 7b7d:Lf, 8bip:Lj, 8bjq:Lj, 8bn3:O7, 8bqd:AF, 8bqx:AF, 7bt6:j, 7btb:j, 6c0f:j, 6cb1:j, 8ccs:V, 8cdl:V, 8cdr:V, 8ceh:V, 8cf5:V, 8cg8:V, 8cgn:V, 8civ:V, 8cku:V, 8cmj:V, 5dat:O7, 5dat:o7, 5dc3:O7, 5dc3:o7, 5dge:O7, 5dge:o7, 5dgf:O7, 5dgf:o7, 5dgv:O7, 5dgv:o7, 6elz:j, 6em1:j, 6em3:j, 6em4:j, 6em5:j, 8eub:Aj, 8evp:Aj, 8evq:Aj, 8evr:Aj, 8evs:Aj, 8evt:Aj, 8ewb:Aj, 8ewc:Aj, 5fci:O7, 5fci:o7, 5fcj:O7, 5fcj:o7, 6ft6:j, 5gak:l, 6gq1:j, 6gqb:j, 6gqv:j, 5h4p:j, 6hd7:l, 8hfr:jh, 6hhq:AK, 6hhq:DL, 5i4l:O7, 5i4l:o7, 6i7o:AF, 6i7o:XF, 3j6x:77, 3j6y:77, 3j77:87, 3j78:87, 3jct:j, 5jcs:j, 5juo:OA, 5jup:OA, 5jus:OA, 5jut:OA, 5juu:OA, 8k2d:Lj, 8k82:Lj, 5lyb:O7, 5lyb:o7, 5m1j:j5, 6m62:j, 5mc6:AF, 5mei:AK, 5mei:DL, 7mpi:Aj, 7mpj:Aj, 6n8j:j, 6n8k:j, 6n8l:j, 6n8m:w, 6n8n:w, 6n8o:w, 7n8b:Aj, 7nac:j, 5ndg:O7, 5ndg:o7, 5ndv:O7, 5ndv:o7, 5ndw:O7, 5ndw:o7, 7nrc:Ll, 7nrd:Ll, 5obm:O7, 5obm:o7, 7of1:j, 7oh3:j, 7ohp:j, 7ohq:j, 7ohr:j, 7ohs:j, 7ohu:j, 7ohv:j, 7ohw:j, 7ohx:j, 7ohy:j, 6oig:j, 5on6:AK, 5on6:DL, 7osa:eL37, 7osm:eL37, 8p8m:RJ, 8p8n:RJ, 8p8u:RJ, 8pfr:RJ, 6q8y:AF, 6qik:i, 6qt0:i, 6qtz:i, 7r7a:j, 6r84:l, 6r86:l, 6r87:l, 6ri5:i, 7rr5:Lj, 6rzz:i, 6s05:i, 6s47:Al, 6snt:ag, 6sv4:AF, 6sv4:XF, 6sv4:zF, 6t4q:Lj, 5t62:w, 5t6r:w, 6t7i:Lj, 6t7t:Lj, 6t83:jb, 6t83:U, 5tbw:AK, 5tbw:DL, 6tb3:AF, 5tga:O7, 5tga:o7, 5tgm:O7, 5tgm:o7, 6tnu:AF, 7too:AL37, 7top:AL37, 7u0h:j, 4u3m:O7, 4u3m:o7, 4u3n:O7, 4u3n:o7, 4u3u:O7, 4u3u:o7, 4u4n:O7, 4u4n:o7, 4u4o:O7, 4u4o:o7, 4u4q:O7, 4u4q:o7, 4u4r:O7, 4u4r:o7, 4u4u:O7, 4u4u:o7, 4u4y:O7, 4u4y:o7, 4u4z:O7, 4u4z:o7, 4u50:O7, 4u50:o7, 4u51:O7, 4u51:o7, 4u52:O7, 4u52:o7, 4u53:O7, 4u53:o7, 4u55:O7, 4u55:o7, 4u56:O7, 4u56:o7, 4u6f:O7, 4u6f:o7, 7ug6:j, 7uoo:j, 7uqb:j, 7uqz:j, 7v08:j, 4v4b:BY, 4v7h:BY, 4v7r:Bd, 4v7r:Dd, 4v88:Bj, 4v88:Dj, 4v8t:j, 4v8y:Bj, 4v8z:Bj, 8v83:j, 8v84:j, 8v87:j, 4v91:j, 6woo:j, 6xiq:j, 6xir:j, 8y0u:Lj, 6ylg:j, 6ylh:j, 6ylx:j, 6yly:j, 5z3g:n, 7z34:j, 6z6j:Lj, 6z6k:Lj, 7zpq:Bi, 7zrs:Bi, 7zs5:Bk, 7zuw:Bi, 7zux:Ei, 7zw0:Lm
8 8eug:j 83 80 0.6279 0.6506 0.6750 7.93e-35 8esq:j, 8esr:j, 8etc:j, 8etg:j, 8eth:j, 8eti:j, 8etj:j, 8eui:j, 8eup:j, 8euy:j, 8ev3:j
9 3j79:c 89 85 0.6279 0.6067 0.6353 1.09e-34 3jbn:Ac, 3jbo:Ac, 3jbp:Ac, 8tpu:Ac, 5umd:c
10 5it7:jj 85 79 0.6279 0.6353 0.6835 1.23e-34 6uz7:Bj
11 7old:Lj 88 81 0.6512 0.6364 0.6914 2.62e-34 8i9p:Lj, 8i9r:Lj, 8i9t:Lj, 8i9v:Lj, 8i9w:Lj, 8i9x:Lj, 8i9y:Lj, 8i9z:Lj, 8ia0:Lj, 7olc:Lj, 8oo0:Lj, 8pv1:Lj, 8pv2:Lj, 8pv3:Lj, 8pv4:Lj, 8pv5:Lj, 8pv6:Lj, 8pv7:Lj, 8pv8:Lj, 8pvk:Lj, 8pvl:Lj, 7r81:l1, 7z3n:Lj, 7z3o:Lj
12 8c3a:AK 86 80 0.5814 0.5814 0.6250 1.53e-31 8c3a:CE, 8cq7:AK, 8cq7:CE, 8cqw:AK, 8cqw:CE, 8cre:AK, 8cre:CE, 8oeq:AK, 8oeq:CE, 7pzy:AK, 7q08:AK, 7q0f:AK, 7q0p:AK, 7q0r:AK, 8q5i:AK
13 9bh5:Cj 88 86 0.6395 0.6250 0.6395 7.32e-29 9cai:Cj
14 5xxb:i 87 84 0.6395 0.6322 0.6548 5.17e-28
15 4v8p:AA 91 87 0.5465 0.5165 0.5402 2.18e-27 4v8p:DA, 4v8p:FA, 4v8p:HA
16 6zj3:Ly 106 72 0.5000 0.4057 0.5972 8.39e-27
17 8brm:Lk 88 76 0.4767 0.4659 0.5395 5.22e-25 8br8:Lk, 8bsi:Lk, 8bsj:Lk, 8btd:Lk, 8btr:Lk, 8fru:j, 7pwg:j, 7pwo:j2
18 5xy3:j 77 75 0.4535 0.5065 0.5200 2.87e-24
19 4v8m:Bn 83 78 0.5116 0.5301 0.5641 6.39e-22 8a3w:j, 8a98:j, 6az3:j, 3jcs:j, 8ova:Bn, 8ove:Bn, 8ovj:j, 8rxh:Lj, 8rxx:Lj, 5t2a:l, 5t5h:n
20 6rm3:LJJ 90 76 0.4651 0.4444 0.5263 4.17e-20
21 6zu5:LJJ 89 78 0.5233 0.5056 0.5769 4.65e-15
22 8p5d:LJJ 89 67 0.3837 0.3708 0.4925 1.38e-14 8p60:LJJ, 8p60:KJJ, 7qca:LJJ
23 7qep:O7 86 76 0.4302 0.4302 0.4868 6.09e-12
24 3cc2:1 56 51 0.2907 0.4464 0.4902 1.45e-10 3cc4:1, 3cc7:1, 3cce:1, 3ccj:1, 3ccl:1, 3ccm:1, 3ccq:1, 3ccr:1, 3ccs:1, 3ccu:1, 3ccv:1, 3cd6:1, 3cma:1, 3cme:1, 3cpw:Z, 3cxc:Z, 1ffk:X, 3g4s:1, 3g6e:1, 3g71:1, 3i55:1, 3i56:1, 1jj2:Z, 1k73:2, 1k8a:2, 1k9m:2, 1kc8:2, 1kd1:2, 1kqs:Z, 1m1k:2, 1m90:2, 1n8r:2, 1nji:2, 2otj:1, 2otl:1, 3ow2:Z, 1q7y:2, 1q81:2, 1q82:2, 1q86:2, 2qa4:1, 2qex:1, 1qvf:Z, 1qvg:Z, 1s72:1, 4v9f:1, 1vq4:1, 1vq5:1, 1vq6:1, 1vq7:1, 1vq8:1, 1vq9:1, 1vqk:1, 1vql:1, 1vqm:1, 1vqn:1, 1vqo:1, 1vqp:1, 1w2b:Z, 1yhq:1, 1yi2:1, 1yij:1, 1yit:1, 1yj9:1, 1yjn:1, 1yjw:1
25 4v4n:Ae 62 49 0.2791 0.3871 0.4898 5.33e-08 4v6u:Be
26 6skf:Bh 62 59 0.3256 0.4516 0.4746 9.08e-08 6skg:Bh, 6th6:Bh
27 8hku:L37E 54 53 0.2674 0.4259 0.4340 7.71e-07 8hkv:L37E, 8hky:L37E, 8hkz:L37E, 8hl1:L37E, 8hl2:L37E, 8hl3:L37E, 8hl4:L37E, 8hl5:L37E
28 7bcz:A 242 72 0.2674 0.0950 0.3194 0.36 7bcz:B, 7bcz:C, 7bcz:D
29 8hky:S27A 54 25 0.1512 0.2407 0.5200 0.48 8hkz:S27A, 8hl1:S27A, 8hl2:S27A, 8hl3:S27A, 8hl4:S27A, 8hl5:S27A, 8wkp:S27A, 8wq2:S27A, 8wq4:S27A
30 2k4x:A 55 34 0.1512 0.2364 0.3824 0.53
31 5jb3:Y 50 37 0.1744 0.3000 0.4054 2.0 5jbh:Y, 6sw9:Y, 6swc:Y, 6swe:Y, 4v4n:BY, 4v6u:AY, 7zag:Y, 7zah:Y, 7zai:Y, 7zhg:Y
32 6tmf:Z 50 33 0.1512 0.2600 0.3939 4.7
33 3egd:B 731 15 0.1163 0.0137 0.6667 5.0 3egx:B, 8hr0:B, 2nup:B, 2nut:B, 5vne:B, 5vnf:B, 5vng:B, 5vnh:B, 5vni:B, 5vnj:B, 5vnk:B, 5vnl:B, 5vnm:B, 5vnn:B, 5vno:B
34 3eh1:A 737 15 0.1163 0.0136 0.6667 5.0
35 2bte:A 876 13 0.1047 0.0103 0.6923 7.3 2bte:D, 2byt:A, 2byt:D, 1h3n:A, 1obc:A, 2v0c:A, 2v0g:A, 2v0g:D
36 4nqa:I 385 24 0.1279 0.0286 0.4583 8.4 4dk7:A, 4dk7:C, 4dk8:A, 4dk8:C, 5hjp:B, 5hjp:D, 5i4v:A, 5i4v:E, 6jio:A, 6jio:D, 5jy3:A, 5jy3:B, 5jy3:C, 5jy3:D, 6k9g:A, 6k9g:B, 6k9g:D, 6k9m:A, 6k9m:B, 6k9m:C, 6k9m:D, 3kfc:A, 3kfc:B, 3kfc:D, 5kya:A, 5kya:E, 5kyj:A, 5kyj:E, 3l0e:A, 4nqa:B, 1p8d:A, 1p8d:B, 1pq6:A, 1pq6:B, 1pq6:D, 1pq9:A, 1pq9:B, 1pq9:C, 1pq9:D, 1pqc:A, 1pqc:B, 1pqc:C, 1pqc:D, 4rak:A, 4rak:B, 6s4n:D, 6s4n:A, 6s4n:B, 6s4n:C, 6s4t:A, 6s4u:A, 6s4u:B, 6s4u:C, 6s5k:A, 1upv:A, 1upw:A
37 7nvr:3 214 28 0.1047 0.0421 0.3214 9.0
38 7egb:0 236 28 0.1047 0.0381 0.3214 9.8 7egc:0

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Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
  • yangzhanglabumich.edu | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218