Department of Computer Science, School of Computing Department of Biochemistry, Yong Loo Lin School of Medicine Cancer Science Institute of Singapore Artificial Intelligence Institute National University of Singapore Computing 1, 13 Computing Drive Singapore 117417 Phone: +65-6601-1241 Email: zhanglabzhanggroup.org We are interested in: AI and Deep Learning Protein and RNA Structure Prediction De Novo Protein and Peptide Design Structure-based Protein Function Annotation SNP Mutation and Genetic Diseases Protein-Protein and Protein-RNA Interactions Ligand Docking and AI-Driven Drug Design

Understanding the structure and function of proteins and RNAs is fundamental to modern biology and medicine. Our lab develops advanced AI-driven algorithms to predict the three-dimensional structures of proteins and RNAs directly from their primary sequences, and to elucidate their biological functions through an integrated sequence–structure–function framework. We further couple computational modeling with biochemical validation to design novel biomolecules, including proteins, peptides and RNAs, with enhanced or entirely new functionalities that transcend those found in nature. ( >> Read more ... ).

• CSI.NUS.EDU.SG (2025/3/19): Novel Sequence Searching Algorithm Significantly Boost the Power of AI-based Protein-Protein Complex Structure Prediction.
• SCIENCENET.CN (2024/12/2): Biao Zhang were awarded prestigious grant supports from both China Postdoctoral Science Foundation and Union Medical College Young Scholar Support Program .
• NSFC.GOV.CN (2024/10/10): Xi Zhang received support from National Natural Science Foundation of China (Young Scientists Fund) and Young Faculty Grant of Peking Union Medical College.

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