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I-TASSER I-TASSER-MTD C-I-TASSER CR-I-TASSER QUARK C-QUARK LOMETS MUSTER CEthreader SEGMER DeepFold DeepFoldRNA FoldDesign COFACTOR COACH MetaGO TripletGO IonCom FG-MD ModRefiner REMO DEMO DEMO-EM DMFold SPRING COTH Threpp PEPPI BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign BindProf BindProfX SSIPe GPCR-I-TASSER MAGELLAN ResQ STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes DeepPotential WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner GPU-I-TASSER

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

BioLiP
>protein
KRTKKAGIVGKYGTRYGASLRKQIKKMEVSQHSKYFCEFCGKFAVKRKAVGIWGCKDCGKVKAGGAYTMNTASAVTVRST
IRRLREQTE

The query sequence (length=89) is searched through a non-redundant set of database sequences protein_nr.fasta.gz clustered at 90% identity cutoff to identify representative hits. Homologs that belong to the same sequence cluster of the representative hit are listed in the last column of the table.

# Hit Hit
length
Aligned
length
Identity
(normalized by query)
Identity
(normalized by hit)
Identity (normalized
by aligned length)
E-value Homologs
to hit
1 4v3p:Lm 92 89 1.0000 0.9674 1.0000 1.09e-60 8azw:a, 8b2l:a3, 8ip8:GB, 8ipa:GB, 8ipb:GB, 8jiv:Cp, 7qiw:q, 7qiz:q, 4v7e:Cp, 1ysh:D
2 5xxb:o 90 87 0.6854 0.6778 0.7011 2.77e-41
3 6zj3:L5 90 89 0.6629 0.6556 0.6629 3.45e-40
4 7olc:Lp 91 89 0.6854 0.6703 0.6854 4.57e-40 8ia0:Lp, 7old:Lp, 8oo0:Lp, 8pv1:Lp, 8pv2:Lp, 8pv3:Lp, 8pv4:Lp, 8pv5:Lp, 8pv6:Lp, 8pv7:Lp, 8pv8:Lp, 8pvk:Lp, 8pvl:Lp, 7r81:r1, 7z3n:Lp, 7z3o:Lp
5 7a01:I2 91 86 0.6966 0.6813 0.7209 7.25e-40 8a3d:j, 5aj0:Ap, 8b5l:p, 8b6c:p, 9bdl:AL43, 9bdn:AL43, 9bdp:AL43, 7bhp:Lp, 8bhf:c1, 8bpo:o2, 8btk:Bp, 7cpu:Lp, 7cpv:Lp, 4d5y:p, 4d67:p, 6d90:p, 6d9j:p, 9f1b:Bp, 9f1c:Bp, 9f1d:Bp, 7f5s:Lp, 8fkz:LX, 8fl2:LX, 8fl3:LX, 8fl4:LX, 8fl6:LX, 8fl7:LX, 8fl9:LX, 8fla:LX, 8flb:LX, 8flc:LX, 8fld:LX, 8fle:LX, 8flf:LX, 6frk:p, 6ftg:p, 6fti:p, 6ftj:p, 8g5y:Lp, 8g5z:Lp, 8g60:Lp, 8g61:Lp, 8g6j:Lp, 8glp:Lp, 6gz3:Ap, 6gz4:Ap, 6gz5:Ap, 6hcf:p3, 6hcj:p3, 6hcm:p3, 6hcq:p3, 8idt:X, 8idy:X, 8ie3:X, 8ifd:2j, 8ife:2j, 8ine:X, 8inf:X, 8ink:X, 6ip5:2j, 6ip6:2j, 6ip8:2j, 8ipd:X, 8ipx:X, 8ipy:X, 8ir1:X, 8ir3:X, 3j7o:p, 3j7p:p, 3j7q:p, 3j7r:p, 3j92:p, 3jag:p, 3jah:p, 3jai:p, 3jaj:p, 3jan:p, 8jdj:u, 8jdk:u, 8jdl:u, 8jdm:u, 8k2c:Lp, 5lks:Lp, 6lqm:X, 6lsr:X, 6lss:X, 7ls1:j2, 7ls2:j2, 6lu8:X, 5lzs:p, 5lzt:p, 5lzu:p, 5lzv:p, 5lzw:p, 5lzx:p, 5lzy:p, 5lzz:p, 7mdz:p, 6mtb:p, 6mtc:p, 6mtd:p, 6mte:p, 7nfx:p, 7nwg:p3, 7nwh:p, 7nwi:p, 7o7y:Bp, 7o7z:Bp, 7o80:Bp, 7o81:Bp, 7obr:p, 8ohd:Lp, 8oj0:Lp, 8oj5:Lp, 8oj8:Lp, 6ole:q, 6olf:q, 6olg:Ap, 6oli:q, 6olz:Ap, 6om0:q, 6om7:q, 7ow7:j, 7oya:p1, 7oyb:p1, 7oyc:p1, 7oyd:p, 8p2k:Bp, 6p5i:Ap, 6p5j:Ap, 6p5k:Ap, 6p5n:Ap, 8q7z:Bp, 8q87:Bp, 8qfd:p, 7qgg:q, 8qoi:Lp, 7qvp:Lp, 7qvp:Mp, 7qwq:p, 7qwr:p, 7qws:p, 6qzp:Lp, 6r5q:p, 6r6g:p, 6r6p:p, 6r7q:p, 8rjb:p, 8rjc:p, 8rjd:p, 8scb:p, 6sgc:p2, 6swa:n, 5t2c:j, 6t59:p3, 7tm3:p, 7toq:AL43, 7tor:AL43, 7tut:p, 7ucj:p, 7uck:p, 4ug0:Lp, 4ujc:Bp, 4ujd:Ap, 4uje:Cp, 4v5z:Bz, 4v6x:Cp, 6w6l:q, 6xa1:Lp, 7xnx:Lp, 7xny:Lp, 8xsx:Lp, 8xsy:Lp, 8xsz:Lp, 6y0g:Lp, 8y0w:Lp, 8y0x:Lp, 6y2l:Lp, 6y57:Lp, 6y6x:Lp, 8yoo:Lp, 8yop:Lp, 6z6l:Lp, 6z6m:Lp, 6z6n:Lp, 7zjw:Lr, 7zjx:Lr, 6zm7:Lp, 6zme:Lp, 6zmi:Lp, 6zmo:Lp, 6zvk:I2
6 9bh5:Cp 88 86 0.7079 0.7159 0.7326 7.99e-40 9cai:Cp
7 8c3a:AQ 91 89 0.6854 0.6703 0.6854 2.42e-39 8c3a:CK, 8cq7:AQ, 8cq7:CK, 8cqw:AQ, 8cqw:CK, 8cre:AQ, 8cre:CK, 8oeq:AQ, 8oeq:CK, 7pzy:AQ, 7q08:AQ, 7q0f:AQ, 7q0p:AQ, 7q0r:AQ, 8q5i:AQ
8 5t2a:m 91 86 0.6517 0.6374 0.6744 5.57e-39 8a3w:o, 8a98:o, 6az3:o, 3jcs:m, 8ova:Bo, 8ove:Bo, 8ovj:o, 8rxh:Lo, 8rxx:Lo, 5t5h:o, 4v8m:Bo
9 4v6i:Bm 92 89 0.6742 0.6522 0.6742 7.98e-39 8aaf:c, 8agt:c, 8agu:c, 8agv:c, 8agw:c, 8agx:c, 8agz:c, 5apn:p, 5apo:p, 7azy:U, 7b7d:Ll, 8bip:Lp, 8bjq:Lp, 8bn3:Q3, 8bqd:AT, 8bqx:AT, 7bt6:p, 7btb:p, 8ccs:b, 8cdl:b, 8cdr:b, 8ceh:b, 8cf5:b, 8cg8:b, 8cgn:b, 8civ:b, 8cku:b, 8cmj:b, 5dat:Q3, 5dat:q3, 5dc3:Q3, 5dc3:q3, 5dge:Q3, 5dge:q3, 5dgf:Q3, 5dgf:q3, 5dgv:Q3, 5dgv:q3, 8eub:Ap, 8evp:Ap, 8evq:Ap, 8evr:Ap, 8evs:Ap, 8evt:Ap, 8ewb:Ap, 8ewc:Ap, 5fci:Q3, 5fci:q3, 5fcj:Q3, 5fcj:q3, 6ft6:p, 5gak:D, 6gq1:p, 6gqb:p, 6gqv:p, 5h4p:p, 6hd7:D, 8hfr:nY, 6hhq:AQ, 6hhq:DR, 5i4l:Q3, 5i4l:q3, 6i7o:AT, 6i7o:XT, 3j6x:83, 3j6y:83, 3j77:93, 3j78:93, 3jct:p, 5jcs:p, 5juo:UA, 5jup:UA, 5jus:UA, 5jut:UA, 5juu:UA, 8k2d:Lp, 8k82:Lp, 5lyb:Q3, 5lyb:q3, 5m1j:p5, 6m62:p, 5mc6:AT, 5mei:AQ, 5mei:DR, 7mpi:Ap, 7mpj:Ap, 6n8j:p, 6n8k:p, 6n8l:p, 6n8m:R, 6n8n:R, 6n8o:R, 7n8b:Ap, 5ndg:Q3, 5ndg:q3, 5ndv:Q3, 5ndv:q3, 5ndw:Q3, 5ndw:q3, 7nrc:Lr, 7nrd:Lr, 5obm:Q3, 5obm:q3, 7of1:p, 7oh3:p, 7ohq:p, 6oig:p, 5on6:AQ, 5on6:DR, 7osa:eL43, 7osm:eL43, 8p8m:RT, 8p8n:RT, 8p8u:RT, 8pfr:RT, 6q8y:AT, 6qik:m, 6qt0:m, 6qtz:m, 6r84:D, 6r86:D, 6r87:D, 6ri5:m, 7rr5:Lp, 6rzz:m, 6s05:m, 6s47:Ar, 6snt:aa, 6sv4:AT, 6sv4:XT, 6sv4:zT, 6t4q:Lp, 5t62:R, 5t6r:R, 6t7i:Lp, 6t7t:Lp, 6t83:pb, 6t83:aa, 5tbw:AQ, 5tbw:DR, 6tb3:AT, 5tga:Q3, 5tga:q3, 5tgm:Q3, 5tgm:q3, 6tnu:AT, 7too:AL43, 7top:AL43, 7u0h:p, 4u3m:Q3, 4u3m:q3, 4u3n:Q3, 4u3n:q3, 4u3u:Q3, 4u3u:q3, 4u4n:Q3, 4u4n:q3, 4u4o:Q3, 4u4o:q3, 4u4q:Q3, 4u4q:q3, 4u4r:Q3, 4u4r:q3, 4u4u:Q3, 4u4u:q3, 4u4y:Q3, 4u4y:q3, 4u4z:Q3, 4u4z:q3, 4u50:Q3, 4u50:q3, 4u51:Q3, 4u51:q3, 4u52:Q3, 4u52:q3, 4u53:Q3, 4u53:q3, 4u55:Q3, 4u55:q3, 4u56:Q3, 4u56:q3, 4u6f:Q3, 4u6f:q3, 7ug6:p, 7uoo:p, 7uqb:p, 7uqz:p, 7v08:p, 4v4b:B9, 4v7f:k, 4v7h:B9, 4v7r:Bg, 4v7r:Dg, 4v88:Bp, 4v88:Dp, 4v8t:p, 4v91:p, 6woo:p, 6xiq:p, 6xir:p, 8y0u:Lp, 6ylg:p, 6ylh:p, 6yly:p, 7z34:p, 6z6j:Lp, 6z6k:Lp, 7zpq:Bo, 7zrs:Bo, 7zs5:BB, 7zuw:Bo, 7zux:Eo, 7zw0:Ls
10 4v6w:Cp 91 89 0.6629 0.6484 0.6629 1.37e-38 6xu6:Cp, 6xu7:Cp, 6xu8:Cp
11 5it7:pp 87 86 0.6404 0.6552 0.6628 1.41e-38 6uz7:Bp
12 5xy3:p 89 86 0.6292 0.6292 0.6512 4.93e-35
13 4v8p:BY 102 86 0.6067 0.5294 0.6279 5.24e-35 4v8p:CY, 4v8p:EY, 4v8p:GY
14 8fru:p 93 89 0.5730 0.5484 0.5730 2.27e-31 8br8:Lq, 8brm:Lq, 8bsi:Lq, 8bsj:Lq, 8btd:Lq, 8btr:Lq, 7pwg:p, 7pwo:p2
15 3j79:h 85 84 0.5843 0.6118 0.6190 6.03e-30 3jbn:Ah, 3jbo:Ah, 3jbp:Ah, 8tpu:Ah, 5umd:h
16 8eug:K 90 88 0.6404 0.6333 0.6477 1.20e-26 8eui:K
17 6zu5:LPP 81 71 0.4944 0.5432 0.6197 6.25e-26
18 8p5d:LPP 87 85 0.4382 0.4483 0.4588 7.98e-22 8p60:LPP, 8p60:KPP, 7qca:LPP
19 7qep:P3 86 71 0.4270 0.4419 0.5352 2.79e-21
20 6rm3:LPP 83 81 0.4157 0.4458 0.4568 4.16e-19
21 6skf:Bg 84 72 0.3371 0.3571 0.4167 1.44e-16 6skg:Bg, 6th6:Bg
22 4v4n:Ai 78 74 0.3483 0.3974 0.4189 7.41e-16 4v6u:Bi
23 4v9f:Z 83 78 0.3146 0.3373 0.3590 7.15e-13 3cc2:Z, 3cc4:Z, 3cc7:Z, 3cce:Z, 3ccj:Z, 3ccl:Z, 3ccm:Z, 3ccq:Z, 3ccr:Z, 3ccs:Z, 3ccu:Z, 3ccv:Z, 3cd6:Z, 3cma:Z, 3cme:Z, 3cpw:Y, 3g4s:Z, 3g6e:Z, 3g71:Z, 3i55:Z, 3i56:Z, 2otj:Z, 2otl:Z, 2qa4:Z, 2qex:Z, 1s72:Z, 1vq4:Z, 1vq5:Z, 1vq6:Z, 1vq7:Z, 1vq8:Z, 1vq9:Z, 1vqk:Z, 1vql:Z, 1vqm:Z, 1vqn:Z, 1vqo:Z, 1vqp:Z, 1yhq:Z, 1yi2:Z, 1yij:Z, 1yit:Z, 1yj9:Z, 1yjn:Z, 1yjw:Z
24 1ffk:W 73 68 0.3034 0.3699 0.3971 1.30e-12
25 3cxc:Y 73 68 0.2809 0.3425 0.3676 1.98e-10 1jj2:Y, 1k73:1, 1k8a:1, 1k9m:1, 1kc8:1, 1kd1:1, 1kqs:Y, 1m1k:1, 1m90:1, 1n8r:1, 1nji:1, 3ow2:Y, 1q7y:1, 1q81:1, 1q82:1, 1q86:1, 1qvf:Y, 1qvg:Y, 1w2b:Y
26 8hku:L37A 65 65 0.3146 0.4308 0.4308 2.78e-08 8hkv:L37A, 8hky:L37A, 8hkz:L37A, 8hl1:L37A, 8hl2:L37A, 8hl3:L37A, 8hl4:L37A, 8hl5:L37A
27 4n0n:A 401 48 0.1798 0.0399 0.3333 0.11 4n0o:A, 4n0o:C, 4n0o:E, 4n0o:G
28 5d9q:D 222 44 0.1685 0.0676 0.3409 0.36 5d9q:I, 5d9q:O, 8san:D, 8san:H, 8san:L, 6vi0:L, 6vi0:D, 6vi0:J
29 3ovg:A 351 34 0.1910 0.0484 0.5000 0.42 3ovg:B, 3ovg:C, 3ovg:D, 3ovg:E, 3ovg:F
30 3rhc:A 103 41 0.1348 0.1165 0.2927 0.82 3rhb:A, 3rhc:B
31 8h1j:A 362 39 0.1798 0.0442 0.4103 1.5 8ex9:A, 8exa:A
32 6l1v:A 129 29 0.1124 0.0775 0.3448 1.8 6l1v:C, 6l1v:E, 6l1v:G, 1rkr:A, 1rkr:B, 1rkr:C, 1rkr:D
33 4qiw:B 1069 76 0.2247 0.0187 0.2632 2.2 4qiw:J
34 3ngb:C 210 44 0.1573 0.0667 0.3182 2.4 5kzc:L, 5kzc:D
35 6kf3:B 1114 76 0.2247 0.0180 0.2632 2.4 9bct:B, 9bcu:B, 6kf4:B, 6kf9:B
36 6bb4:L 211 34 0.1124 0.0474 0.2941 4.1 6bb4:M, 6bb4:N
37 7aoh:B 1134 43 0.1573 0.0123 0.3256 6.6 7amv:B, 7aof:B, 7aoz:B, 7ap8:B, 7ap9:B, 8c8h:B, 6rfl:B, 6ric:B, 6rid:B, 6rie:B
38 8p0j:B 1155 43 0.1573 0.0121 0.3256 6.6 8p0k:B, 8p0n:B
39 7rsn:L 101 43 0.1348 0.1188 0.2791 7.6 7rsn:J, 7rsn:K
40 7ej6:B 316 22 0.1236 0.0348 0.5000 7.7 7ej6:C, 7ej6:A, 7ej7:B, 7ej7:A, 7ej7:C
41 4xcq:A 303 47 0.1573 0.0462 0.2979 9.2

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Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
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